Efficient kinetic resolution in the asymmetric transfer hydrogenation of 3-aryl-indanones: applications to a short synthesis of (+)-indatraline and a formal synthesis of (R)-tolterodine
Keyword(s):
Efficient kinetic resolution occurs in ATH of racemic 3-arylindanones using (R,R)-or (S,S)-Ts-DENEB catalyst and HCO2H/Et3N mixture providing near equal yields of cis-3-arylindanols and unreacted 3-arylindanones with excellent stereoselectivities.
2015 ◽
Vol 21
(33)
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pp. 11799-11806
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2014 ◽
Vol 79
(6)
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pp. 2666-2681
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2012 ◽
Vol 77
(12)
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pp. 5454-5460
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