505. Mechanism of electrophilic substitution at a saturated carbon atom. Part I. Scope and plan. Optical activity from a single asymmetric carbon atom bearing a metal

1959 ◽  
pp. 2523 ◽  
Author(s):  
H. B. Charman ◽  
E. D. Hughes ◽  
Christopher Ingold
Keyword(s):  
Carbon Atom ◽  
Optical Activity ◽  
Electrophilic Substitution ◽  
Asymmetric Carbon Atom ◽  
Saturated Carbon Atom ◽  
Asymmetric Carbon

scholarly journals The symmetrical spiro -heptanediamine and its resolution into optically active components

1936 ◽  
Vol 154 (881) ◽  
pp. 53-60 ◽  
Keyword(s):  
Carbon Atom ◽  
Optical Activity ◽  
Optically Active ◽  
Active Components ◽  
Asymmetric Carbon Atom ◽  
Molecular Configuration ◽  
Experimental Realization ◽  
Asymmetric Carbon ◽  
Acetic Acids

The experimental realization of the simplest possible types of molecular configuration which can show optical activity in the amorphous con­dition is important in connexion with stereochemical theory. Among optically active spiranes containing no asymmetric carbon atom such simple types are found in the d - and l -1-methyl- cyclo -hexylidene-4-acetic acids and the d - and 1-spiro- 5:5-dihydantoins, but no satisfactory case has hitherto been described of optical activity in substances of the constitution H —C—( CH 2 ) n —C—(CH 2 ) n —X X —C—( CH 2 ) n —C—(CH 2 ) n —H. One of the simplest conceivable examples of the latter kind should be found in the previously unknown symmetrical spiro -heptanediamine of the constitution— NH 2 —C—CH 2 —C—CH 2 —C—H H—C—CH 2 —C—CH 2 —C—NH 2 .

On the Relation of Optical Activity to the Character of the Radicals united to the Asymmetric Carbon Atom

1891 ◽  
Vol 17 ◽  
pp. 181-185 ◽  
Author(s):  
Crum Brown
Keyword(s):  
Carbon Atom ◽  
Optical Activity ◽  
Numerical Representation ◽  
Asymmetric Carbon Atom ◽  
The Difference ◽  
Asymmetric Carbon

It is obvious that the amount of the optical activity of a given compound containing an asymmetric atom of carbon depends upon the amount of difference in character among the four radicals united to the asymmetric carbon atom, so that if two of them are very nearly equal we come very near to a compound of a symmetric carbon atom, in which the optical activity is zero. The question suggests itself, How are we to measure this difference of character ? We shall assume that there is a function, capable of numerical representation, derivable from the composition and constitution of the radical and the temperature of the substance, and that it is the difference between the values of this function in the case of two radicals which gives us the difference of character referred to. For the sake of brevity, we may call this function the K of the radical. The object of this paper is to show that, if there be such a function, there are methods by means of which we may hope to ascertain its value in each case.

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