Chiral recognition of prochiral centres and general acid-base catalysis. Necessarily interrelated manifestations of active-site structure
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On the basis of Ogston's [(1948) Nature (London) 162, 963] argument, the following conclusions are indicated by the stereochemistry of the reversible oxidation of glycollate by lactate dehydrogenase: (1) general acid-base catalysis is involved in the reaction; (2) the transformation of enzyme-bound (tetrahedral) substrate into enzyme-bound (trigonal) product involves a conformational transition of the enzyme-coenzyme complex.
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1989 ◽
Vol 264
(9)
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pp. 4939-4947
2006 ◽
Vol 445
(2)
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pp. 199-213
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2018 ◽
Vol 57
(29)
◽
pp. 8906-8910
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