A Fab fragment directed against the neural cell adhesion molecule L1 enhances functional recovery after injury of the adult mouse spinal cord

2014 ◽  
Vol 460 (3) ◽  
pp. 437-446 ◽  
Author(s):  
Gabriele Loers ◽  
Yi-Fang Cui ◽  
Irmgard Neumaier ◽  
Melitta Schachner ◽  
Arne Skerra
Keyword(s):  
Spinal Cord ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Functional Recovery ◽  
Cell Adhesion Molecule ◽  
Fab Fragment ◽  
Cord Injury ◽  
Cell Adhesion Molecule L1 ◽  
Fibronectin Type Iii Domain

A recombinant monovalent Fab fragment recognizing a functional epitope within the third fibronectin type III domain of murine cell adhesion molecule L1 induces neurite outgrowth and neuronal survival in vitro and enhances functional recovery after spinal cord injury in mice.

Schwann cells engineered to express the cell adhesion molecule L1 accelerate myelination and motor recovery after spinal cord injury

2010 ◽  
Vol 221 (1) ◽  
pp. 206-216 ◽  
Author(s):  
Alexandros A. Lavdas ◽  
Jian Chen ◽  
Florentia Papastefanaki ◽  
Suzhen Chen ◽  
Melitta Schachner ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Adhesion ◽  
Schwann Cells ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Motor Recovery ◽  
Cord Injury ◽  
Cell Adhesion Molecule L1

Soluble Cell Adhesion Molecule L1-Fc Promotes Locomotor Recovery in Rats after Spinal Cord Injury

2003 ◽  
Vol 20 (9) ◽  
pp. 871-882 ◽  
Author(s):  
Chanland Roonprapunt ◽  
Wencheng Huang ◽  
Ray Grill ◽  
David Friedlander ◽  
Martin Grumet ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Locomotor Recovery ◽  
Soluble Cell ◽  
Cord Injury ◽  
Cell Adhesion Molecule L1
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