Urinary Adenosine Cyclic 3',5'-Monophosphate in Idiopathic Calcium Stone-Formers

1985 ◽  
Vol 69 (1) ◽  
pp. 109-110 ◽  
Author(s):  
P. A. Baghurst
Keyword(s):  
Cyclic Amp ◽  
Normal Subjects ◽  
Clinical Science ◽  
Oral Calcium ◽  
Calcium Stone ◽  
Stone Formers ◽  
Calcium Load ◽  
Urinary Cyclic Amp

Walker & Sutton in Clinical Science (1984, 66, 193-199) [1] have compared changes in urinary cyclic AMP excretion in response to an oral calcium load given to normal subjects with corresponding changes in idiopathic calcium stone-formers.

Urinary Adenosine Cyclic 3′,5′-Monophosphate in Idiopathic Calcium Stone-Formers: Response to An Oral Calcium Load

1984 ◽  
Vol 66 (2) ◽  
pp. 193-199 ◽  
Author(s):  
V. R. Walker ◽  
R. A. L. Sutton
Keyword(s):  
Cyclic Amp ◽  
Excretion Rate ◽  
Normal Subjects ◽  
Oral Calcium ◽  
Calcium Stone ◽  
Stone Formers ◽  
Glomerular Filtrate ◽  
Calcium Load ◽  
Urinary Cyclic Amp ◽  
Lower Urinary

1. Idiopathic calcium stone-formers with hypercalciuria during fasting have significantly lower urinary cyclic AMP levels (nmol/dl of glomerular filtrate) than fasting normocalciuric stone-formers. 2. Female subjects, including both normal subjects and idiopathic calcium stone-formers, have higher urinary cyclic AMP levels than their male counterparts, and this difference is significant when urinary cyclic AMP is expressed in the units μmol/g of creatinine. Expressing urinary cyclic AMP in nmol/dl of glomerular filtrate reduces this difference but does not abolish it. Thus, in comparing urinary cyclic AMP levels in various subgroups of the calcium stone-formers and in normal subjects, both sex differences and the units of urinary cyclic AMP expression must be taken into consideration. 3. The magnitude of the change in urinary cyclic AMP in response to an oral calcium load appears to depend on the antecedent urinary cyclic AMP excretion rate, whereby those individuals (either normal subjects or calcium stone-formers) having the highest urinary cyclic AMP levels demonstrate the greatest fall in urinary cyclic AMP after a calcium load.

Stimulation of calcitonin secretion by an oral calcium load test in normal subjects and in idiopathic renal stone formers

1991 ◽  
Vol 13 (2) ◽  
pp. 131-137 ◽  
Author(s):  
M. Fuss ◽  
T. Pepersack ◽  
J. Corvilain ◽  
P. Bergmann ◽  
D. Willems ◽  
...  
Keyword(s):  
Renal Stone ◽  
Normal Subjects ◽  
Load Test ◽  
Oral Calcium ◽  
Stone Formers ◽  
Calcium Load ◽  
Calcitonin Secretion ◽  
Stimulation Of

Chemical factors important to calcium nephrolithiasis: evidence for impaired hydroxycarboxylic acid absorption causing hyperoxaluria.

1987 ◽  
Vol 33 (2) ◽  
pp. 243-247 ◽  
Author(s):  
D M Cowley ◽  
B C McWhinney ◽  
J M Brown ◽  
A H Chalmers
Keyword(s):  
Stone Formation ◽  
Urine Volume ◽  
Normal Subjects ◽  
Concurrent Administration ◽  
Calcium Stone ◽  
Hydroxycarboxylic Acids ◽  
Stone Formers ◽  
Daily Excretion ◽  
Chemical Factors ◽  
Urinary Oxalate Excretion

Abstract An investigation of variables important to calcium stone formation in urine indicated significantly increased daily excretion of calcium and oxalate and decreased excretion of ascorbate and citrate by recurrent calcium stone formers. In addition, urine volume, sodium, mucopolysaccharide, and protein were also significantly increased. We compared the uptake of citrate and ascorbate from the gut into the blood in normal controls and stone formers. These studies indicated significantly depressed absorption of both these hydroxycarboxylic acids in recurrent calcium stone formers. We also found that concurrent administration of citrate inhibited ascorbate absorption and increased urinary oxalate excretion after an ascorbate load in normal subjects and stone formers. These findings suggest a mechanism that explains hyperoxaluria in stone patients on the basis of a malabsorption of citrate, ascorbate, and possibly other hydroxycarboxylic acids.

Oral calcium tolerance test and serum calcitonin in calcium stone formers

1983 ◽  
Vol 11 (1) ◽  
pp. 33-37 ◽  
Author(s):  
K. Kohri ◽  
K. Kataoka ◽  
M. Iguchi ◽  
S. Yachiku ◽  
T. Kurita
Keyword(s):  
Tolerance Test ◽  
Serum Calcitonin ◽  
Oral Calcium ◽  
Calcium Stone ◽  
Calcium Tolerance ◽  
Stone Formers

Oral calcium tolerance and urinary cyclic amp in urolithiasis

Urology ◽  
1978 ◽  
Vol 12 (5) ◽  
pp. 519-524 ◽  
Author(s):  
James H. Nelson ◽  
Herbert W. Riemenschneider ◽  
Bryan Pflug ◽  
William K. Whitehouse ◽  
Roberta A. Rehm ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Oral Calcium ◽  
Calcium Tolerance ◽  
Urinary Cyclic Amp

Urinary and nephrogenous cyclic AMP and renal phosphate handling in normal subjects and patients with parathyroid dysfunction

1984 ◽  
Vol 106 (2) ◽  
pp. 219-226
Author(s):  
S. Khoury ◽  
J. R. Tucci
Keyword(s):  
Cyclic Amp ◽  
Primary Hyperparathyroidism ◽  
Normal Subjects ◽  
Normal Group ◽  
Permanent Hypoparathyroidism ◽  
Urinary Cyclic Amp ◽  
Parathyroid Dysfunction

Abstract. Studies were performed in 60 patients with proven primary hyperparathyroidism pre-operatively and in 54 of these patients post-operatively, 22 patients with permanent hypoparathyroidism and 34 normal subjects. Urinary and nephrogenous cyclic AMP excretion were increased in the hyperparathyroid patients with an overlap of values with the normal group of 10 and 9%, respectively. Values fell in all patients post-operatively, and were decreased in those with permanent hypoparathyroidism. TmPO4/GFR was decreased in the preoperative hyperparathyroid patients and rose postoperatively while it was increased in the hypoparathyroid patients with an overlap of values with the normal group of 9%. Post-operative hypocalcaemia due to bone hunger was associated with continuing normo- or hypophosphataemia and urinary cyclic AMP that exceeded 4.5 nm/dl GF while those who developed permanent hypoparathyroidism had hyperphosphataemia, increased TmPO4/GFR and urinary cyclic AMP that was less than 3.5 nM/dl G.F. Urinary and nephrogenous cyclic AMP were equally effective in characterizing patients with primary hyperparathyroidism and less effective in distinguishing patients with hypoparathyroidism from normal while TmPO4/GFR estimates were more effective in delineating the hypoparathyroid state.

The Influence of Glucose and Crude Fibre (Wheat Bran) on the Rate of Intestinal 47Ca Absorption The Influence of Glucose and Wheat Bran on Calcium Absorption

1979 ◽  
Vol 65 (3) ◽  
pp. 143-146
Author(s):  
M. A. Macleod ◽  
N. J. Blacklock
Keyword(s):  
Urinary Excretion ◽  
Wheat Bran ◽  
Calcium Absorption ◽  
Normal Subjects ◽  
Calcium Balance ◽  
Theoretical Possibility ◽  
Crude Fibre ◽  
Calcium Stone ◽  
Negative Calcium Balance ◽  
Stone Formers

AbstractWith evidence of induction of increased urinary excretion of calcium by the ingestion of glucose and sucrose there is the theoretical possibility in these circumstances of at least a transient negative calcium balance. In this study the ingestion of glucose or glucose equivalent was found to stimulate 47Ca absorption from the intestine both in normal subjects and in idiopathic calcium stone formers. This induced increase in the rate of 47Ca absorption by glucose can be negated by the addition of crude fibre in the form of wheat bran.

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