Glucose-6-phosphatase in normal adult human intestinal mucosa
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1. The existence of specific glucose-6-phosphatase activity in human intestinal mucosa has been somewhat controversial. 2. We have demonstrated the presence of low levels of specific glucose-6-phosphatase activity in normal human adult intestinal mucosa. Activity was found in oesophagus, stomach, duodenum and colon. 3. Immunoblot analysis using antibodies monospecific for the 36.5 kDa liver glucose-6-phosphatase catalytic subunit demonstrated that intestinal mucosa contains low levels of the glucose-6-phosphatase enzyme protein. 4. The low levels of activity together with problems of proteolysis make human intestinal biopsies unsuitable for use in the diagnosis of type 1 glycogen-storage disease.
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1995 ◽
Vol 154
(6)
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pp. 483-487
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2015 ◽
pp. 307-317
1992 ◽
Vol 56
(3)
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pp. 587-592
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2000 ◽
Vol 276
(11)
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pp. 7963-7967
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1990 ◽
Vol 52
(6)
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pp. 1043-1050
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