scholarly journals Ziprasidone and the activity of cytochrome P450 2D6 in healthy extensive metabolizers

2000 ◽  
Vol 49 (S1) ◽  
pp. 43-47 ◽  
Author(s):  
K. D. Wilner ◽  
S. B. Demattos ◽  
R. J. Anziano ◽  
G. Apseloff ◽  
N. Gerber ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Extensive Metabolizers ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

Effects of type 1 and type 2 diabetes on the pharmacokinetics of tramadol enantiomers in patients with neuropathic pain phenotyped as cytochrome P450 2D6 extensive metabolizers

2014 ◽  
Vol 66 (9) ◽  
pp. 1222-1230 ◽  
Author(s):  
Natália Valadares de Moraes ◽  
Gabriela Rocha Lauretti ◽  
Vera Lucia Lanchote
Keyword(s):  
Type 2 Diabetes ◽  
Neuropathic Pain ◽  
Cytochrome P450 ◽  
Extensive Metabolizers ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

scholarly journals Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: Preliminary findings

2010 ◽  
Vol 16 (5) ◽  
pp. 890-901 ◽  
Author(s):  
MARIANA CHERNER ◽  
CHAD BOUSMAN ◽  
IAN EVERALL ◽  
DANIEL BARRON ◽  
SCOTT LETENDRE ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Exposure ◽  
Neuropsychological Performance ◽  
Metabolic Clearance ◽  
Extensive Metabolizers ◽  
Cytochrome P450 2D6 ◽  
Hepatitis C Infection ◽  
Similar Drug ◽  
Other Substances ◽  
P450 2D6

AbstractWhile neuropsychological deficits are evident among methamphetamine (meth) addicts, they are often unrelated to meth exposure parameters such as lifetime consumption and length of abstinence. The notion that some meth users develop neuropsychological impairments while others with similar drug exposure do not, suggests that there may be individual differences in vulnerability to the neurotoxic effects of meth. One source of differential vulnerability could come from genotypic variability in metabolic clearance of meth, dependent on the activity of cytochrome P450-2D6 (CYP2D6). We compared neuropsychological performance in 52 individuals with a history of meth dependence according with their CYP2D6 phenotype. All were free of HIV or hepatitis C infection and did not meet dependence criteria for other substances. Extensive metabolizers showed worse overall neuropsychological performance and were three times as likely to be cognitively impaired as intermediate/poor metabolizers. Groups did not differ in their demographic or meth use characteristics, nor did they evidence differences in mood disorder or other substance use. This preliminary study is the first to suggest that efficient meth metabolism is associated with worse neurocognitive outcomes in humans, and implicates the products of oxidative metabolism of meth as a possible source of brain injury. (JINS, 2010, 16, 890–901.)

Cytochrome P450 2D6 polymorphism in Lebanon. (c2003)

2003 ◽  
Author(s):  
Sarita Georges Saade
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

The Association Between Cytochrome P450 2D6 Genotype and Prescription Patterns of Antipsychotic and Antidepressant Drugs in Hospitalized Psychiatric Patients

2005 ◽  
Vol 25 (2) ◽  
pp. 188-191 ◽  
Author(s):  
Hans Mulder ◽  
Frederik W. Wilmink ◽  
Tim L. Beumer ◽  
Wim J. Tamminga ◽  
Jaap N. Jedema ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Psychiatric Patients ◽  
Antidepressant Drugs ◽  
Cytochrome P450 2D6 ◽  
Prescription Patterns ◽  
P450 2D6

Probing Small-Molecule Binding to Cytochrome P450 2D6 and 2C9: An In Silico Protocol for Generating Toxicity Alerts

ChemMedChem ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. 2088-2101 ◽  
Author(s):  
Gianluca Rossato ◽  
Beat Ernst ◽  
Martin Smiesko ◽  
Morena Spreafico ◽  
Angelo Vedani
Keyword(s):  
Cytochrome P450 ◽  
Small Molecule ◽  
In Silico ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

From Genotype to Phenotype: Cytochrome P450 2D6-Mediated Drug Clearance in Humans

2017 ◽  
Vol 14 (3) ◽  
pp. 649-657 ◽  
Author(s):  
Jie Gao ◽  
Xin Tian ◽  
Jun Zhou ◽  
Ming-Zhu Cui ◽  
Hai-Feng Zhang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Clearance ◽  
Cytochrome P450 2D6 ◽  
P450 2D6
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