Absence of anaplastic lymphoma kinase (ALK) and Epstein-Barr virus gene products in primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis

1997 ◽  
Vol 137 (5) ◽  
pp. 680-686 ◽  
Author(s):  
H. HERBST ◽  
C. SANDER ◽  
M. TRONNIEK ◽  
H. KUTZNER ◽  
H. HÜGEL ◽  
...  
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Gene Products ◽  
Lymphomatoid Papulosis ◽  
Barr Virus ◽  
Anaplastic Lymphoma ◽  
Large Cell Lymphoma ◽  
Epstein Barr

Epstein–Barr Virus-Associated Anaplastic Large Cell Lymphoma in Renal Transplant Patients

1992 ◽  
Vol 98 (3) ◽  
pp. 312-318 ◽  
Author(s):  
Bettina Borisch ◽  
Kevin C. Gatter ◽  
Andreas Tobler ◽  
L. Theilkäs ◽  
Christopher Bunch ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Anaplastic Large Cell Lymphoma ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Barr Virus ◽  
Transplant Patients ◽  
Large Cell Lymphoma ◽  
Renal Transplant Patients ◽  
Epstein Barr

scholarly journals Metagenomic analysis to identify novel infectious agents in systemic anaplastic large cell lymphoma

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Parag Mahale ◽  
Jason Nomburg ◽  
Joo Y. Song ◽  
Mia Steinberg ◽  
Gabriel Starrett ◽  
...  
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Metagenomic Analysis ◽  
Breast Cancers ◽  
Barr Virus ◽  
Large Cell Lymphoma ◽  
Epstein Barr ◽  
Positive Controls

AbstractSystemic anaplastic large cell lymphoma (ALCL) is a rare CD30-expressing T-cell non-Hodgkin lymphoma. Risk of systemic ALCL is highly increased among immunosuppressed individuals. Because risk of cancers associated with viruses is increased with immunosuppression, we conducted a metagenomic analysis of systemic ALCL to determine whether a known or novel pathogen is associated with this malignancy. Total RNA was extracted and sequenced from formalin-fixed paraffin-embedded tumor specimens from 19 systemic ALCL cases (including one case from an immunosuppressed individual with human immunodeficiency virus infection), 3 Epstein-Barr virus positive diffuse large B-cell lymphomas (DLBCLs) occurring in solid organ transplant recipients (positive controls), and 3 breast cancers (negative controls). We used a pipeline based on the Genome Analysis Toolkit (GATK)-PathSeq algorithm to subtract out human RNA reads and map the remaining RNA reads to microbes. No microbial association with ALCL was identified, but we found Epstein-Barr virus in the DLBCL positive controls and determined the breast cancers to be negative. In conclusion, we did not find a pathogen associated with systemic ALCL, but because we analyzed only one ALCL tumor from an immunosuppressed person, we cannot exclude the possibility that a pathogen is associated with some cases that arise in the setting of immunosuppression.

Prevalence and characterization of anaplastic large cell lymphoma and its association with Epstein-Barr virus in Pakistani patients

2004 ◽  
Vol 200 (10) ◽  
pp. 669-679 ◽  
Author(s):  
Samina Noorali ◽  
Shahid Pervez ◽  
Nausheen Yaqoob ◽  
Tariq Moatter ◽  
Muhammad Israr Nasir ◽  
...  
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Barr Virus ◽  
Large Cell Lymphoma ◽  
Epstein Barr
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