Course of eosinophil cationic protein in the nasal secretions of patients with seasonal allergic rhinitis

Concentration of the Eosinophil Cationic Protein (ECP) measured in different body fluids has been demonstrated to be a good marker of eosinophilic inflammation. In allergic asthma, ECP levels in both broncho-alveolar-lavage (BAL) fluid and serum can be used to monitor disease activity. In allergic rhinitis, the value of ECP determinations in serum and nasal secretions was not directly compared, so far. In the present study, ECP levels in blood serum (Se) and nasal secretions (NS) of grass pollen allergic and healthy individuals under pollen exposure were analyzed. Forty-three grass-pollen allergic subjects and 19 healthy volunteers were included. Grass-pollen counts were measured using Burkhard traps and a symptom scoring performed. In the allergic subjects, the mean ECP concentration in nasal secretions was 789 ± 515 ng/mL compared with 12.1 ± 7.4 ng/mL in serum; in the healthy volunteers it was 29.6 ± 15.4 ng/mL in NS compared to 9.4 ± 6.9 ng/mL in Se. ECP concentration in NS was significantly higher in allergic than in healthy subjects (P < 0.001) and in both significantly higher than in Se (P < 0.01). ECP concentration in Se did not differ significantly in patients and healthy volunteers (P > 0.05). In the allergic subjects, ECP concentration in NS but not in Se was closely correlated to symptom score and pollen exposure. We conclude that ECP levels in NS are a better marker of eosinophilic inflammation in allergic rhinitis than ECP serum levels.

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α2-Macroglobulin and eosinophil cationic protein in the allergic airway mucosa in seasonal allergic rhinitis

CrossRef Listing of Deleted DOIs ◽

10.1183/09031936.99.13363399 ◽

1999 ◽

Vol 13 (3) ◽

pp. 633-637 ◽

Cited By ~ 16

Author(s):

P. Meyer ◽

C.G.A. Persson ◽

M. Andersson ◽

P. Wollmer ◽

M. Linden ◽

...

Keyword(s):

Allergic Rhinitis ◽

Seasonal Allergic Rhinitis ◽

Eosinophil Cationic Protein ◽

Cationic Protein ◽

Airway Mucosa

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Serum Eosinophil Cationic Protein (ECP) Levels in Patients with Seasonal Allergic Rhinitis and Allergic Asthma

Allergy and Asthma Proceedings ◽

10.2500/108854188778607228 ◽

1998 ◽

Vol 19 (2) ◽

pp. 69-73 ◽

Cited By ~ 9

Author(s):

Aytul Sin ◽

Ender Terzioğlu ◽

Ali Kokuludağ ◽

Filiz Sebik ◽

Tomris Kabakçi

Keyword(s):

Allergic Rhinitis ◽

Allergic Asthma ◽

Seasonal Allergic Rhinitis ◽

Eosinophil Cationic Protein ◽

Cationic Protein

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Traditional Chinese MedicineZHENGIdentification Provides a Novel Stratification Approach in Patients with Allergic Rhinitis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/480715 ◽

2012 ◽

Vol 2012 ◽

pp. 1-9 ◽

Cited By ~ 7

Author(s):

Kai-Li Liang ◽

Rong-San Jiang ◽

Chia-Lin Lee ◽

Pei-Jung Chiang ◽

Jui-Shan Lin ◽

...

Keyword(s):

Allergic Rhinitis ◽

Immunoglobulin E ◽

Linear Regression Analysis ◽

Eosinophil Cationic Protein ◽

Multiple Linear Regression Analysis ◽

Total Serum ◽

Blood Eosinophil ◽

Cationic Protein ◽

Explanatory Factors ◽

Severity Scores

Background. We aimed to apply theZHENGidentification to provide an easy and useful tool to stratify the patients with allergic rhinitis (AR) through exploring the correlation between the quantified scores of AR symptoms and the TCMZHENGs.Methods. A total of 114 AR patients were enrolled in this observational study. All participants received the examinations of anterior rhinoscopy and acoustic rhinometry. Their blood samples were collected for measurement of total serum immunoglobulin E (IgE), blood eosinophil count (Eos), and serum eosinophil cationic protein (ECP). They also received two questionnaire to assess the severity scores of AR symptoms and quantified TCMZHENGscores. Multiple linear regression analysis was used to determine explanatory factors for the score of AR manifestations.Results. IgE and ECP level, duration of AR, the 2 derived TCMZHENGscores of “Yin-Xu − Yang-Xu”, and “Qi-Xu+Blood-Xu” were 5 explanatory variables to predict the severity scores of AR symptoms. The patients who had higher scores of “Yin-Xu − Yang-Xu” or “Qi-Xu+Blood-Xu” tended to manifest as “sneezer and runner” or “blockers,” respectively.Conclusions.The TCMZHENGscores correlated with the severity scores of AR symptoms and provided an easy and useful tool to stratify the AR patients.

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