Drug resistance of herpes simplex virus type 1. Structural considerations at the molecular level of the thymidine kinase

Molecular Level ◽

Herpes simplex virus type 1 UL46 and UL47 deletion mutants lack VP11 and VP12 or VP13 and VP14, respectively, and exhibit altered viral thymidine kinase expression.

Journal of Virology ◽

10.1128/jvi.67.3.1482-1492.1993 ◽

1993 ◽

Vol 67 (3) ◽

pp. 1482-1492 ◽

Cited By ~ 63

Author(s):

Y Zhang ◽

J L McKnight

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Virus Type ◽

Deletion Mutants ◽

Simplex Virus ◽

Kinase Expression

Purification and photoaffinity labeling of herpes simplex virus type-1 thymidine kinase

Antiviral Research ◽

10.1016/0166-3542(95)94863-w ◽

1995 ◽

Vol 26 (3) ◽

pp. A314

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Virus Type ◽

Photoaffinity Labeling ◽

Mechanism of resistance to acyclovir in thymidine kinase mutants from Herpes simplex virus type 1: a computational approach

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2019.1625443 ◽

2019 ◽

Vol 38 (7) ◽

pp. 2116-2127 ◽

Cited By ~ 1

Author(s):

Vitor Won-Held Rabelo ◽

Nelilma Correia Romeiro ◽

Izabel Christina Nunes de Palmer Paixão ◽

Paula Alvarez Abreu

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Virus Type ◽

Computational Approach ◽

Mechanism Of Resistance ◽

Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.93.8.3525 ◽

1996 ◽

Vol 93 (8) ◽

pp. 3525-3529 ◽

Cited By ~ 202

Author(s):

M. E. Black ◽

T. G. Newcomb ◽

H. M. Wilson ◽

L. A. Loeb

Keyword(s):

Gene Therapy ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Virus Type ◽

Characterization of Multiple Nuclear Localization Signals in Herpes Simplex Virus Type 1 Thymidine Kinase

Biochemical and Biophysical Research Communications ◽

10.1006/bbrc.1999.1485 ◽

1999 ◽

Vol 264 (2) ◽

pp. 338-342 ◽

Cited By ~ 13

Author(s):

Bart Degrève ◽

Robert Esnouf ◽

Erik De Clercq ◽

Jan Balzarini

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Virus Type ◽

Nuclear Localization ◽

Nuclear Localization Signals ◽

(E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity

Biochemical Pharmacology ◽

10.1016/0006-2952(89)90494-2 ◽

1989 ◽

Vol 38 (12) ◽

pp. 1955-1961 ◽

Cited By ~ 7

Author(s):

Ria Bernaerts ◽

Claude Desoranges ◽

Erik De Clercq

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Antiviral Activity ◽

Thymidine Kinase ◽

Virus Type ◽

Effect on substrate binding of an alteration at the conserved aspartic acid-162 in herpes simplex virus type 1 thymidine kinase

Journal of General Virology ◽

10.1099/0022-1317-77-7-1521 ◽

1996 ◽

Vol 77 (7) ◽

pp. 1521-1527 ◽

Cited By ~ 10

Author(s):

M. E. Black ◽

T. M. Rechtin ◽

R. R. Drake

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Aspartic Acid ◽

Virus Type ◽

Substrate Binding ◽

Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes

Antiviral Research ◽

10.1016/j.antiviral.2007.08.009 ◽

2008 ◽

Vol 77 (1) ◽

pp. 77-80 ◽

Cited By ~ 15

Author(s):

Yan Sergerie ◽

Guy Boivin

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Dna Polymerase ◽

Virus Type ◽

Resistant Strains ◽

Different Mechanisms of Inhibition of DNA Synthesis by (E)-5-(2-Bromovinyl)-2′-deoxyuridine in Cells Transfected with Gene for Thymidine Kinase of Herpes Simplex Virus Type 1 and in Cells Infected with the Virus

Nucleosides and Nucleotides ◽

10.1080/15257779508010725 ◽

1995 ◽

Vol 14 (9-10) ◽

pp. 2079-2087 ◽

Cited By ~ 1

Author(s):

Yasuhide Hirota ◽

Yujiro Arao ◽

Akiko Matsumoto ◽

Shiro Nii ◽

Yusuke Wataya

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Dna Synthesis ◽

Thymidine Kinase ◽

Virus Type ◽

Simplex Virus ◽

Inhibition Of Dna Synthesis ◽

In Cells

MicroPET imaging of Cre–loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene

Gene Therapy ◽

10.1038/sj.gt.3302194 ◽

2004 ◽

Vol 11 (7) ◽

pp. 609-618 ◽

Cited By ~ 16

Author(s):

G Sundaresan ◽

R Paulmurugan ◽

F Berger ◽

B Stiles ◽

Y Nagayama ◽

...

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Reporter Gene ◽

Virus Type ◽

Micropet Imaging ◽