photoaffinity labeling
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Effect of Alkynyl Group on Reactivity in Photoaffinity Labeling with 2‐Thienyl‐Substituted α‐Ketoamide

2022 ◽  
Author(s):  
Takahiro Moriyama ◽  
Daiki Mizukami ◽  
Makoto Yoritate ◽  
Kazuteru Usui ◽  
Daisuke Takahashi ◽  
...  
Keyword(s):  
Photoaffinity Labeling

scholarly journals Target identification of baicalein derivative using DNA-programmed photoaffinity labeling

2021 ◽  
pp. 100014
Author(s):  
Yuxiao Tang ◽  
Xiaobin Zhuo ◽  
Yan Cao ◽  
Diya Lv ◽  
Langdong Chen ◽  
...  
Keyword(s):  
Target Identification ◽  
Photoaffinity Labeling

A photoaffinity labeling strategy identified EF1A1 as a binding protein of cyclic dinucleotide 2′3′-cGAMP

2021 ◽  
Author(s):  
Yingjie Hou ◽  
Heng Lu ◽  
Jinxin Li ◽  
Zhenyu Guan ◽  
Jianan Zhang ◽  
...  
Keyword(s):  
Binding Protein ◽  
Photoaffinity Labeling ◽  
Cyclic Dinucleotide

scholarly journals Protocol for clickable photoaffinity labeling and quantitative chemical proteomics

2021 ◽  
Vol 2 (2) ◽  
pp. 100593
Author(s):  
Wankyu Lee ◽  
Zhen Huang ◽  
Christopher W. am Ende ◽  
Uthpala Seneviratne
Keyword(s):  
Photoaffinity Labeling ◽  
Chemical Proteomics ◽  
Quantitative Chemical

scholarly journals Structure, bonding, and photoaffinity labeling applications of dialkyldiazirines

Synlett ◽  
2021 ◽  
Author(s):  
Tianyi Zhang ◽  
Alison Ondrus
Keyword(s):  
Mass Spectrometry ◽  
Small Molecule ◽  
Protein Interactions ◽  
Photoaffinity Labeling ◽  
Mass Spectrometry Analysis ◽  
Practical Application ◽  
Basic Principles ◽  
Spectrometry Analysis ◽  
Photoaffinity Probes ◽  
Photoaffinity Crosslinking

Dialkyldiazirine photoaffinity probes are unparalleled tools for the study of small molecule-protein interactions. Here we summarize the basic principles of structure, bonding, and photoreactivity of dialkyldiazirines, current methods for their synthesis, and their practical application in photoaffinity labeling experiments. We demonstrate the unique utility of dialkyldiazirine probes in the context of our recent photoaffinity crosslinking-mass spectrometry analysis to reveal a hidden cholesterol binding site in the Hedgehog morphogen proteins.

Clickable gold-nanoparticles as generic probe precursors for facile photoaffinity labeling application

2021 ◽  
Author(s):  
Kanna Mori ◽  
Kaori Sakurai
Keyword(s):  
Gold Nanoparticles ◽  
Small Molecules ◽  
Photoaffinity Labeling ◽  
Protein Analysis ◽  
Target Protein ◽  
Photoaffinity Probes ◽  
One Step

Clickable photoreactive gold nanoparticles have been developed to facilitate one-step preparation of photoaffinity probes for bioactive small molecules and their application to target protein analysis.

Synthesis of (Trifluoromethyldiazirinyl)phenylboronic Acid Derivatives for Photoaffinity Labeling

Heterocycles ◽  
2021 ◽  
Vol 103 (1) ◽  
pp. 392
Author(s):  
Makoto Hashimoto ◽  
Manami Hashinoki ◽  
Natsumi Kurokawa ◽  
Yuta Murai ◽  
Zetryana Puteri Tachrim ◽  
...  
Keyword(s):  
Phenylboronic Acid ◽  
Photoaffinity Labeling

scholarly journals Recent progress in the use of diaziridine-based sweetener derivatives to elucidate the chemoreception mechanism of the sweet taste receptor

RSC Advances ◽  
2021 ◽  
Vol 11 (51) ◽  
pp. 32236-32247
Author(s):  
Makoto Hashimoto ◽  
Tomoya Nakagita ◽  
Takumi Misaka
Keyword(s):  
Recent Progress ◽  
Photoaffinity Labeling ◽  
Taste Receptor ◽  
Sweet Taste ◽  
Sweet Taste Receptor

The review summarized recent progress for the elucidation of the chemoreception mechanism of sweet taste receptor–sweetener interactions with photoaffinity labeling.

scholarly journals Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor

2020 ◽  
Vol 15 (12) ◽  
pp. 3106-3111
Author(s):  
Dimitris Korovesis ◽  
Nicole Rufo ◽  
Rita Derua ◽  
Patrizia Agostinis ◽  
Steven H. L. Verhelst
Keyword(s):  
Photoaffinity Labeling

scholarly journals Probing the Mechanism of Photoaffinity Labeling by Dialkyldiazirines through Bioorthogonal Capture of Diazoalkanes

2020 ◽  
Vol 22 (24) ◽  
pp. 9415-9420
Author(s):  
Jessica G. K. O’Brien ◽  
Andrew Jemas ◽  
Papa Nii Asare-Okai ◽  
Christopher W. am Ende ◽  
Joseph M. Fox
Keyword(s):  
Photoaffinity Labeling
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