Nuchal translucency screening and antenatal maternal serum screening for Down syndrome: results of a project

Prenatal screening for Down syndrome should be offered to all pregnant women. The screening option chosen will be influenced by maternal preference, local availability of tests, and the gestation at which the pregnant woman presents. Screening tests take into account the effect of maternal age on Down syndrome risk. The combined first trimester screen using nuchal translucency and first trimester maternal serum screening can achieve a detection rate for Down syndrome of 90% with a 5% false positive rate, when performed by appropriately trained individuals. Midtrimester maternal serum screening is a good screening option for women unable to undergo the combined first trimester screen.

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Women's interpretation of an abnormal result on measurement of fetal nuchal translucency and maternal serum screening for prenatal testing of Down syndrome

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.2845 ◽

2006 ◽

Vol 28 (3) ◽

pp. 242-248 ◽

Cited By ~ 15

Author(s):

B. Khoshnood ◽

C. De Vigan ◽

B. Blondel ◽

A. Lhomme ◽

V. Vodovar ◽

...

Keyword(s):

Down Syndrome ◽

Prenatal Testing ◽

Nuchal Translucency ◽

Maternal Serum ◽

Abnormal Result ◽

Maternal Serum Screening ◽

Serum Screening

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Comparison and integration of first trimester fetal nuchal translucency and second trimester maternal serum screening for fetal Down syndrome

Prenatal Diagnosis ◽

10.1002/pd.382 ◽

2002 ◽

Vol 22 (8) ◽

pp. 730-735 ◽

Cited By ~ 13

Author(s):

Yung Hang Lam ◽

Chin Peng Lee ◽

Sai Yuen Sin ◽

Rebecca Tang ◽

Hong Soo Wong ◽

...

Keyword(s):

Down Syndrome ◽

First Trimester ◽

Nuchal Translucency ◽

Maternal Serum ◽

Second Trimester ◽

Maternal Serum Screening ◽

Serum Screening

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First trimester ultrasound identifies more cases of Down syndrome than second trimester maternal serum screening and is more cost effective

PsycEXTRA Dataset ◽

10.1037/e556492006-009 ◽

2003 ◽

Keyword(s):

Down Syndrome ◽

Cost Effective ◽

First Trimester ◽

Maternal Serum ◽

Second Trimester ◽

Maternal Serum Screening ◽

Serum Screening ◽

First Trimester Ultrasound

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Maternal Serum Screening for Down Syndrome by Using Alpha-Fetoprotein and Human Chorionic Gonadotropin in an Asian Population

Fetal Diagnosis and Therapy ◽

10.1159/000020986 ◽

2000 ◽

Vol 15 (2) ◽

pp. 108-111 ◽

Cited By ~ 10

Author(s):

Hei-Jen Jou ◽

Ming-Kwang Shyu ◽

Shih-Ming Chen ◽

Jin-Chung Shih ◽

Jenn-Jeih Hsu ◽

...

Keyword(s):

Down Syndrome ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Asian Population ◽

Maternal Serum ◽

Alpha Fetoprotein ◽

Maternal Serum Screening ◽

Serum Screening

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Second-trimester Down syndrome maternal serum screening in twin pregnancies: impact of chorionicity

Prenatal Diagnosis ◽

10.1002/pd.594 ◽

2003 ◽

Vol 23 (4) ◽

pp. 331-335 ◽

Cited By ~ 43

Author(s):

Fran�oise Muller ◽

Sophie Dreux ◽

Henry Dupoizat ◽

Serge Uzan ◽

Marie-Fran�oise Dubin ◽

...

Keyword(s):

Down Syndrome ◽

Maternal Serum ◽

Second Trimester ◽

Maternal Serum Screening ◽

Serum Screening ◽

Twin Pregnancies

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How important is consent in maternal serum screening for Down syndrome in France? Information and consent evaluation in maternal serum screening for Down syndrome: a French study

Prenatal Diagnosis ◽

10.1002/pd.1656 ◽

2007 ◽

Vol 27 (3) ◽

pp. 197-205 ◽

Cited By ~ 30

Author(s):

Romain Favre ◽

Nathalie Duchange ◽

Christophe Vayssière ◽

Monique Kohler ◽

Nicole Bouffard ◽

...

Keyword(s):

Down Syndrome ◽

Maternal Serum ◽

Maternal Serum Screening ◽

French Study ◽

Serum Screening

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Maternal Serum Screening for Fetal Down Syndrome in Women Less Than 35 Years of Age Using Alpha-Fetoprotein, hCG, and Unconjugated Estriol: A Prospective 2-Year Study

Journal of Diagnostic Medical Sonography ◽

10.1177/875647939300900123 ◽

1993 ◽

Vol 9 (1) ◽

pp. 47-48

Keyword(s):

Down Syndrome ◽

Maternal Serum ◽

Alpha Fetoprotein ◽

Maternal Serum Screening ◽

Serum Screening ◽

Unconjugated Estriol

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Screening for Down syndrome in the first trimester

Reproduction Fertility and Development ◽

10.1071/rd9951413 ◽

1995 ◽

Vol 7 (6) ◽

pp. 1413 ◽

Cited By ~ 1

Author(s):

KJ Powell ◽

JG Grudzinskas

Keyword(s):

Down Syndrome ◽

First Trimester ◽

Maternal Blood ◽

Maternal Serum ◽

Published Data ◽

Maternal Serum Screening ◽

Ultrasound Findings ◽

Serum Screening ◽

Associated Proteins ◽

Trimester Screening

Second-trimester maternal serum screening for Down syndrome is now well established, and permits detection of up to 70% of cases. The disadvantage of this sort of screening is that the timing of maternal blood sampling is relatively late (after 15 weeks). There is an accumulating body of evidence to suggest that in the first trimester concentrations of a number of pregnancy-associated proteins and hormones differ in chromosomally normal and abnormal pregnancies. A first-trimester maternal serum screening test for Down syndrome may therefore be possible. In addition, new methods of screening have recently been described based on ultrasound findings at 11 to 13 weeks of gestation. This review article presents a discussion of published data on the feasibility of first-trimester screening for Down syndrome.

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