Caspase cleavage of the amyloid precursor protein modulates amyloid β-protein toxicity

2003 ◽  
Vol 87 (3) ◽  
pp. 733-741 ◽  
Author(s):  
Daniel C. Lu ◽  
Salvador Soriano ◽  
Dale E. Bredesen ◽  
Edward H. Koo
Keyword(s):  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Amyloid Β Protein ◽  
Caspase Cleavage ◽  
Β Protein ◽  
Protein Toxicity

scholarly journals Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein

2003 ◽  
Vol 278 (27) ◽  
pp. 24294-24301 ◽  
Author(s):  
Toru Sato ◽  
Naoshi Dohmae ◽  
Yue Qi ◽  
Nobuto Kakuda ◽  
Hiroaki Misonou ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Amyloid Β Protein ◽  
Terminal Fragment ◽  
Β Protein ◽  
Potential Link ◽  
Β Amyloid

Protein lipidation of BACE

2005 ◽  
Vol 33 (5) ◽  
pp. 1091-1093 ◽  
Author(s):  
R.B. Parsons ◽  
B.M. Austen
Keyword(s):  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Amyloid Β Protein ◽  
Lipid Modification ◽  
Β Protein ◽  
Aβ Amyloid ◽  
Protein Lipidation

Our research has concentrated upon the protein lipid modification of BACE [β-site amyloid precursor protein cleaving enzyme (β-secretase)], of which very little is currently known. Lipidation influences the production of Aβ (amyloid β-protein) by promoting the dimerization of BACE.

scholarly journals Induced Dimerization of the Amyloid Precursor Protein Leads to Decreased Amyloid-β Protein Production

2009 ◽  
Vol 284 (42) ◽  
pp. 28943-28952 ◽  
Author(s):  
Simone Eggert ◽  
Brea Midthune ◽  
Barbara Cottrell ◽  
Edward H. Koo
Keyword(s):  
Amyloid Precursor Protein ◽  
Protein Production ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Amyloid Β Protein ◽  
Β Protein
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