Crohn's Disease Recurrence in a Small Bowel Transplant

Abstract Small bowel transplant is an acceptable procedure for intractable Crohn’s disease (CD). Some case reports and small series describe the apparent recurrence of CD in the transplanted bowel. This commentary discusses evidence in favor of and against this alleged recurrence and argues that a molecular characterization is needed to prove or disprove that inflammation emerging in the transplanted bowel is a true recurrence of the original CD.

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952 The Role of Genetic Crohn's Disease Susceptibility Loci in Small Bowel Transplant Outcome

Gastroenterology ◽

10.1016/s0016-5085(10)60636-1 ◽

2010 ◽

Vol 138 (5) ◽

pp. S-139

Author(s):

Marcel Janse ◽

Rinse K. Weersma ◽

Gerard Dijkstra ◽

Eleonora A. Festen ◽

Debra L. Sudan ◽

...

Keyword(s):

Crohn’S Disease ◽

Small Bowel ◽

Crohn's Disease ◽

Disease Susceptibility ◽

Susceptibility Loci ◽

Transplant Outcome ◽

Small Bowel Transplant

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Mesalamine for prophylaxis of small bowel Crohn’s disease recurrence

Current Gastroenterology Reports ◽

10.1007/s11894-999-0018-2 ◽

1999 ◽

Vol 1 (5) ◽

pp. 377-383 ◽

Cited By ~ 1

Author(s):

William M. Bauer ◽

Aaron Brzezinski ◽

Bret A. Lashner

Keyword(s):

Crohn’S Disease ◽

Small Bowel ◽

Crohn's Disease ◽

Disease Recurrence

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Intestinal ultrasound and management of small bowel Crohn’s disease

Therapeutic Advances in Gastroenterology ◽

10.1177/1756284818771367 ◽

2018 ◽

Vol 11 ◽

pp. 175628481877136 ◽

Cited By ~ 7

Author(s):

Torsten Kucharzik ◽

Christian Maaser

Keyword(s):

Crohn’S Disease ◽

Small Bowel ◽

Crohn's Disease ◽

Disease Recurrence ◽

Primary Diagnosis ◽

New Developments ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography ◽

Bowel Imaging

As Crohn’s disease (CD) is predominantly located within the small bowel, imaging of the small bowel plays an intriguing role in the primary diagnosis as well as in the monitoring of patients with CD. Intestinal ultrasound (IUS) offers several advantages over endoscopy and other imaging modalities. Obvious advantages of IUS include noninvasiveness, rapid availability and cost effectiveness. IUS has been shown to have high accuracy in detecting small bowel CD and determining intra- and extramural complications such as stenoses, fistulae and abscesses. IUS has also been shown to be highly effective in determining postoperative disease recurrence and in follow up of patients under treatment. The following review summarizes current developments in the use of IUS for the detection of small bowel lesions and complications. The aim of this review is to suggest algorithms on how to use IUS in managing patients with small bowel CD in clinical practice. Suggested applications on the use of high frequency IUS in CD are extended by discussing new developments such as contrast-enhanced ultrasonography and elastography.

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