scholarly journals Induction of intestinal sucrase-isomaltase in suckling rats after hydrocortisone injections and substrate administration

1979 ◽  
Vol 19 (3B) ◽  
pp. 795-799
Author(s):  
F. RAUL ◽  
Patricia SIMON ◽  
Michèle KEDINGER ◽  
Katy HAFFEN
1993 ◽  
Vol 265 (3) ◽  
pp. G459-G466 ◽  
Author(s):  
C. Foltzer-Jourdainne ◽  
J. C. Garaud ◽  
E. Nsi-Emvo ◽  
F. Raul

The regulatory effect of epidermal growth factor (EGF) on the postnatal maturation of sucrase was investigated in the small intestine of suckling and weanling rats. Administration of EGF (0.5 micrograms.g body wt-1.day-1) to suckling rats caused a slight precocious induction of sucrase expression. In weanling rats EGF markedly stimulated sucrase activity; however, at both ages, the effect of hydrocortisone was more potent. When the glucocorticoid antagonist RU-38486 was administered to sucklings, the precocious induction of sucrase activity by hydrocortisone was inhibited by 80%. However, RU-38486 or adrenalectomy did not prevent the inductive effect of EGF, indicating that EGF acts in a glucocorticoid-independent manner. EGF also potentiated the effect of hydrocortisone and dietary sucrose on the precocious induction of sucrase activity in the sucklings. At weaning, administration of an antiserum specific to rat EGF significantly decreased sucrase activity. This study shows the involvement of EGF in the postnatal maturation of intestinal sucrase in the rat.


Enzyme ◽  
1983 ◽  
Vol 30 (1) ◽  
pp. 54-58 ◽  
Author(s):  
Thomas Paul ◽  
Gebhard Flatz

1997 ◽  
Vol 127 (4) ◽  
pp. 648-654 ◽  
Author(s):  
Yoko Nakashima ◽  
Saeko Ohsawa ◽  
Keizo Umegaki ◽  
Sachie Ikegami

2013 ◽  
Vol 154 (3) ◽  
pp. 387-395 ◽  
Author(s):  
Elmouldi Garoui ◽  
Ibtissem Ben Amara ◽  
Dorra Driss ◽  
Awatef Elwej ◽  
Semia Ellouze Chaabouni ◽  
...  

Author(s):  
Krista Kostial ◽  
Maja Blanuša ◽  
Martina Piasek ◽  
Nada Restek-Samaržija ◽  
Mark M. Jones ◽  
...  

Neonatology ◽  
2003 ◽  
Vol 84 (2) ◽  
pp. 152-158 ◽  
Author(s):  
Danuta Kruszewska ◽  
Pawel Kiela ◽  
Åsa Ljungh ◽  
Kennedy H. Erlwanger ◽  
Björn R. Weström ◽  
...  

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