Pancreatic islet transplantation in the treatment of diabetes mellitus

2001 ◽  
Vol 15 (2) ◽  
pp. 241-264 ◽  
Author(s):  
A.M.James Shapiro ◽  
Edmond A. Ryan ◽  
Jonathan R.T. Lakey
Keyword(s):  
Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation ◽  
Treatment Of Diabetes

Diabetes mellitus-associated decrease in nerve growth factor levels is reversed by allogeneic pancreatic islet transplantation

1991 ◽  
Vol 125 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Rainer Hellweg ◽  
Manfred Wöhrle ◽  
Heinz-Dieter Hartung ◽  
Hilmar Stracke ◽  
Christoph Hock ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation ◽  
Nerve Growth

scholarly journals Gene Therapy to Improve Pancreatic Islet Transplantation for Type 1 Diabetes Mellitus

2010 ◽  
Vol 6 (5) ◽  
pp. 274-284 ◽  
Author(s):  
Amy Hughes ◽  
Claire Jessup ◽  
Chris Drogemuller ◽  
Daisy Mohanasundaram ◽  
Clyde Milner ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Therapy ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation

First Brazilian pancreatic islet transplantation in a patient with type 1 diabetes mellitus

2004 ◽  
Vol 36 (4) ◽  
pp. 1117-1118 ◽  
Author(s):  
F.G Eliaschewitz ◽  
C.A.M Aita ◽  
T Genzini ◽  
I.L Noronha ◽  
F.H Lojudice ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation

Aspects of pancreatic islet transplantation in diabetes mellitus

1989 ◽  
Vol 3 (4) ◽  
pp. 851-863 ◽  
Author(s):  
Claes Hellerström ◽  
Arne Andersson ◽  
Olle Korsgren ◽  
Leif Jansson ◽  
Stellan Sandler
Keyword(s):  
Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation

scholarly journals Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes

2021 ◽  
Vol 12 ◽  
Author(s):  
Fritz Cayabyab ◽  
Lina R. Nih ◽  
Eiji Yoshihara
Keyword(s):  
Graft Survival ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Complex Disease ◽  
Blood Glucose Monitoring ◽  
Great Promise ◽  
Islet Graft ◽  
Pancreatic Islet Transplantation ◽  
Post Transplantation ◽  
Treatment Of Diabetes

Diabetes is a complex disease that affects over 400 million people worldwide. The life-long insulin injections and continuous blood glucose monitoring required in type 1 diabetes (T1D) represent a tremendous clinical and economic burdens that urges the need for a medical solution. Pancreatic islet transplantation holds great promise in the treatment of T1D; however, the difficulty in regulating post-transplantation immune reactions to avoid both allogenic and autoimmune graft rejection represent a bottleneck in the field of islet transplantation. Cell replacement strategies have been performed in hepatic, intramuscular, omentum, and subcutaneous sites, and have been performed in both animal models and human patients. However more optimal transplantation sites and methods of improving islet graft survival are needed to successfully translate these studies to a clinical relevant therapy. In this review, we summarize the current progress in the field as well as methods and sites of islet transplantation, including stem cell-derived functional human islets. We also discuss the contribution of immune cells, vessel formation, extracellular matrix, and nutritional supply on islet graft survival. Developing new transplantation sites with emerging technologies to improve islet graft survival and simplify immune regulation will greatly benefit the future success of islet cell therapy in the treatment of diabetes.

scholarly journals Pancreatic Islet Transplantation and Regeneration for Diabetes mellitus Treatment

2008 ◽  
Vol 62 (6) ◽  
pp. 199-208
Author(s):  
Dmitry Babarykin ◽  
Vizma Nikolajeva ◽  
Daina Eze ◽  
Diana Amerika
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cells ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Successful Outcome ◽  
Pancreatic Islet Transplantation ◽  
Clinical Islet Transplantation ◽  
Sedentary Life Style ◽  
Almost All ◽  
Diabetes Mellitus Treatment

Pancreatic Islet Transplantation and Regeneration for Diabetes mellitus Treatment The incidence of diabetes mellitus due to different causes (heredity, unhealthy food, sedentary life style, etc.) is increasing both in Latvia and worldwide every year. In almost all cases insulin therapy must be administered. However, the latest modern technologies promote the development of new and alternative treatments of diabetes mellitus. One of them, the procedure of islet transplantation is comparatively simple and relatively non-invasive in contrast to whole pancreas transplantation. It is considered as a perspective strategy in the treatment of patients with type 1 diabetes, when the insulin-producing beta cells have been destroyed and blood glucose level is above the normal range (hyperglycaemia). Successful outcome of clinical islet transplantation has been shown in several islet transplantation centres in Europe and elsewhere, particularly in the last seven years, using corticoid-free immunosuppression regimen. Islets are isolated by a collagenase-based digestion of donor pancreas with a "Ricordi" chamber, followed by a purification step in a Ficoll-based continuous density gradient. This review discusses the islet transplantation procedure and deals with the methods of islet isolation. Importance of islet preparations and engraftment quality, as well as clinical outcome and its indications also are described. The present status of islet regeneration including beta cells neogenesis and regeneration therapy strategies also are presented. The experience of Latvian scientists in islet transplantation procedure is briefly described.

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