A Preliminary Study of a New Tranexamic Acid Dosing Schedule for Cardiac Surgery

2008 ◽  
Vol 22 (2) ◽  
pp. 230-235 ◽  
Author(s):  
Gregory A. Nuttall ◽  
Maria Cristina Gutierrez ◽  
Jonathan D. Dewey ◽  
Michael E. Johnson ◽  
Lance J. Oyen ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Tranexamic Acid ◽  
Dosing Schedule ◽  
Preliminary Study

Comparison of Tranexamic-Acid and Aprotinin regarding the outcome after cardiac surgery

2011 ◽  
Vol 59 (S 01) ◽  
Author(s):  
A Cetinkaya ◽  
A Van Linden ◽  
Z Szalay ◽  
A Afflerbach ◽  
J Blumenstein ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Tranexamic Acid

scholarly journals Influence of Sternotomy on Delta Pulse Pressure and Delta Down During Open Chest Cardiac Surgery: A Preliminary Study

2019 ◽  
Vol 33 (8) ◽  
pp. 2201-2207 ◽  
Author(s):  
Eric Deflandre ◽  
Simon Delande ◽  
Jerome Cauvain ◽  
Pierre Geradon ◽  
Anne-Francoise Donneau ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Pulse Pressure ◽  
Open Chest ◽  
Preliminary Study

Hemostatic Parameters and Platelet Activation Marker Expression in Cyanotic and Acyanotic Pediatric Patients Undergoing Cardiac Surgery in the Presence of Tranexamic Acid

2000 ◽  
Vol 83 (01) ◽  
pp. 54-59 ◽  
Author(s):  
Elena Levin ◽  
John Wu ◽  
John Alexander ◽  
Clayton Reichart ◽  
Suvro Sett ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Platelet Activation ◽  
Pediatric Patients ◽  
Factor Xiiia ◽  
Congenital Defects ◽  
Plasma Factor ◽  
Pai 1 ◽  
D Dimer

SummaryWe have investigated hemostatic parameters including platelet activation in 56 pediatric patients with or without cyanosis undergoing cardiopulmonary bypass (CPB) and cardiac surgery to repair congenital defects. Patients were participants in a study assessing the effects of tranexamic acid on surgery-related blood loss. Parameters monitored included blood loss, prothrombin F1.2, thrombin-antithrombin complexes, t-PA, PAI-1, plasminogen, fibrin D-dimer, and plasma factor XIII. Additionally, flow cytometry monitored platelet degranulation (P-selectin or CD63), as well as surface-bound fibrinogen, von Willebrand factor and factor XIIIa. Cyanotic patients had evidence of supranormal coagulation activation as both fibrin D-dimer and PAI-1 levels were elevated prior to surgery. While the extent of expression of Pselectin or CD63 was not informative, platelet-associated factor XIIIa was elevated in cyanotic patients at baseline. In both patient groups, CPB altered platelet activation state and coagulation status irrespective of the use of tranexamic acid.

The Influence of Aprotinin and Tranexamic Acid on Platelet Function and Postoperative Blood Loss in Cardiac Surgery

2008 ◽  
Vol 107 (2) ◽  
pp. 391-397 ◽  
Author(s):  
Andinet M. Mengistu ◽  
Kerstin D. Röhm ◽  
Joachim Boldt ◽  
Jochen Mayer ◽  
Stefan W. Suttner ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Platelet Function ◽  
Postoperative Blood Loss

Tranexamic Acid Administration During On-Pump Cardiac Surgery

2017 ◽  
Vol 125 (6) ◽  
pp. 1863-1870 ◽  
Author(s):  
Jessica Spence ◽  
Steven Long ◽  
Antonella Tidy ◽  
Karen Raymer ◽  
P. J. Devereaux ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Tranexamic Acid ◽  
Acid Administration

The Efficacy of Tranexamic Acid Versus Placebo in Decreasing Blood Loss in Pediatric Patients Undergoing Repeat Cardiac Surgery

1997 ◽  
Vol 84 (5) ◽  
pp. 990-996 ◽  
Author(s):  
Robert W. Reid ◽  
A. Andrew Zimmerman ◽  
Peter C. Laussen ◽  
John E. Mayer ◽  
Jed B. Gorlin ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Pediatric Patients ◽  
Acid Versus
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