Tranexamic Acid: When is It Indicated in Orthopaedic Surgery?

2021 ◽  
Author(s):  
Bjarke Viberg
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Joint Replacement ◽  
Orthopaedic Surgery ◽  
Thromboembolic Events ◽  
Reduce Blood Loss ◽  
Fracture Surgery ◽  
Arthroscopic Procedures

AbstractTranexamic acid (TXA) has been studied extensively during the last 5–8 years. It inhibits clot dissolution during surgery and can therefore reduce blood loss. However, there has been concern that this could result in more frequent complications, specifically in terms of thromboembolic events. The indications for TXA are widespread, and this review covers the literature on orthopaedic indications such as joint replacement, fracture surgery, and arthroscopic procedures. In general, TXA is safe and can be used in a wide variety of orthopaedic procedures, lowering blood loss without increasing the risk of complications.

Efficacy and safety of tranexamic acid in hip fracture surgery: A comparative study of 613 patients

2021 ◽  
pp. 175045892110020
Author(s):  
Mutaz AlSumadi ◽  
Aatif Mahmood ◽  
David Whittam ◽  
Lara Kharma ◽  
Rami Ashour ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Blood Transfusion ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Thromboembolic Events ◽  
Allogenic Blood ◽  
Hip Fracture Surgery ◽  
Estimated Blood Loss ◽  
Fracture Surgery ◽  
Postoperative Haemoglobin

Background Blood loss is a major concern in the frail elderly patient undergoing hip fracture surgery. The objective of this study was to investigate the efficacy of tranexamic acid in reducing blood loss and allogenic blood transfusions. The study also investigated the safety profile by comparing rates of thromboembolic events, Methods A total of 613 patients with hip fractures were included in the study. Patients received 1g of tranexamic acid on induction of anaesthesia. Postoperative haemoglobin was measured on day one. Blood loss was calculated, and blood transfusion was recorded. Results Tranexamic acid use resulted in a higher mean postoperative haemoglobin (110.3 ± 15.9 vs 106.8 ± 16.2; p = 0.023) and reduced mean estimated blood loss (571.3 ± 150.4 vs 678.3 ± 201.2; p = 0.001). There was also a significantly reduced number of transfusions in tranexamic acid group (13% vs 28%; p = 0.002). There was no difference in rates of deep vein thrombosis (4 vs 3; p = 0.98) or pulmonary embolism (2 vs 2; p = 1). Conclusion The use of tranexamic acid is effective in reduction of blood loss and rates of blood transfusion, without an apparent increase in adverse thromboembolic events.

scholarly journals Does Tranexamic Acid Reduce Blood Loss in Acetabular Fracture Surgery?

2019 ◽  
Author(s):  
Jared Atchison ◽  
Syed Zaidi ◽  
Blessing Eno ◽  
Michael Schloss ◽  
Alexandra Mulliken ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Acetabular Fracture ◽  
Reduce Blood Loss ◽  
Fracture Surgery

scholarly journals Intra-Articular Injection of Tranexamic Acid to Reduce Blood Loss after Total Knee Arthroplasty

2014 ◽  
Vol 22 (2) ◽  
pp. 146-149 ◽  
Author(s):  
Bob Jang ◽  
Mark Kao ◽  
Martin T Bohm ◽  
Ian A Harris ◽  
Darren B Chen ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Reduce Blood Loss ◽  
Total Knee

Can We Safely Reduce Blood Loss During Lumbar Pedicle Subtraction Osteotomy Procedures Using Tranexamic Acid or Aprotinin?

Spine ◽  
2010 ◽  
Vol 35 (2) ◽  
pp. 235-239 ◽  
Author(s):  
Christine R. Baldus ◽  
Keith H. Bridwell ◽  
Lawrence G. Lenke ◽  
Gbolahan O. Okubadejo
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Pedicle Subtraction Osteotomy ◽  
Reduce Blood Loss ◽  
Lumbar Pedicle

Use of Tranexamic Acid to Reduce Blood Loss in Liposuction

2018 ◽  
Vol 141 (5) ◽  
pp. 1132-1135 ◽  
Author(s):  
Alvaro Luiz Cansancao ◽  
Alexandra Condé-Green ◽  
Joshua A. David ◽  
Bethania Cansancao ◽  
Rafael A. Vidigal
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Reduce Blood Loss
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