Successful bevacizumab therapy for CNS radiation necrosis after stereotactic radiotherapy of an arteriovenous malformation

2011 ◽  
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RE Wurm
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Emmanuel Touboul ◽  
Laurent Buffat ◽  
Louis Merienne ◽  
Michel Schlienger ◽  
...  

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Tatsuya Yoshida ◽  
Atsushi Natsume ◽  
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Yasushi Yatabe

1990 ◽  
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R Johnston ◽  
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J H Adams ◽  
...  

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Tadashi Ishida

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Vol 139 ◽  
pp. S98
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Vol 4 (6) ◽  
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...  

A 55-year-old woman underwent radiosurgery for a left cerebral hemisphere arteriovenous malformation (AVM) and developed radiation-induced necrosis causing a massive edema in the surrounding brain tissues. Despite various therapies, the edema expanded to the ipsilateral hemisphere and induced neurological symptoms. The radiation-induced necrotic lesion was surgically removed 4 years after radiosurgery. While the preoperative FDG PET revealed severe hypometabolism in the left cerebrum, the necrotomy significantly ameliorated the brain edema, glucose metabolism (postoperative FDG PET), and symptoms. This case indicates that radiation necrosis-induced neurological deficits may be associated with brain edema and hypometabolism, which could be reversed by appropriate necrotomy.


Author(s):  
Emmanuel Touboul ◽  
Assem Al Halabi ◽  
Laurent Buffat ◽  
Louis Merienne ◽  
Judith Huart ◽  
...  

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