Cerebellar Infarction and Coarctation of the Aorta - causal relation or coincidence?

Coarctation of the aorta (CoA) can present with different clinical pictures depending on the severity of the narrowness in the coarcted aortic segment in an age range between newborn and adolescence. Sometimes, it can cause intracranial hemorrhage or infarction when diagnosis and treatment are delayed. The aim of this report is taking attention to CoA as a cause of systemic hypertension and is also emphasizing the differences of diagnostic approach for hypertension in children from adults. Two cases of hypertensive cerebral hemorrhage and one case of hypertensive cerebellar infarction associated with CoA are reported. These cases help us to pay attention to the possibility of CoA in adolescents with hypertensive stroke. We want to emphasize the importance of physical examination for evaluation of hypertension and to impress the diagnostic approach for secondary hypertension in children.

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Coarctation of the Aorta and Cerebellar Infarction

Pediatric Emergency Care ◽

10.1097/01.pec.0000113888.10140.33 ◽

2004 ◽

Vol 20 (2) ◽

pp. 121-125 ◽

Cited By ~ 2

Author(s):

Martin I. Herman ◽

Bruce Alpert

Keyword(s):

Coarctation Of The Aorta ◽

Cerebellar Infarction

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Cerebellar infarction secondary to subclavian aortoplasty repair for coarctation of the aorta

International Journal of Cardiology ◽

10.1016/0167-5273(87)90086-6 ◽

1987 ◽

Vol 17 (3) ◽

pp. 336-338 ◽

Cited By ~ 6

Author(s):

W.J. Brawn ◽

Samuel Menahem ◽

Roger B.B. Mee

Keyword(s):

Coarctation Of The Aorta ◽

Cerebellar Infarction

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Moving beyond the “LDL hypothesis”

VASA ◽

10.1024/0301-1526/a000451 ◽

2015 ◽

Vol 44 (5) ◽

pp. 333-340 ◽

Cited By ~ 7

Author(s):

Christian Werner ◽

Ulrich Laufs

Keyword(s):

Ldl Cholesterol ◽

Causal Relation ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Clinical Trial Data ◽

Randomised Clinical Trial ◽

Trial Data ◽

Low Density Lipoprotein Cholesterol ◽

Genetic Studies ◽

Statin Drug

Abstract. Summary: The term “LDL hypothesis” is frequently used to describe the association of low-density lipoprotein cholesterol (LDL-cholesterol, LDL-C) and cardiovascular (CV) events. Recent data from genetic studies prove a causal relation between serum LDL-C and CV events. These data are in agreement with mechanistic molecular studies and epidemiology. New randomised clinical trial data show that LDL-C lowering with statins and a non-statin drug, ezetimibe, reduces CV events. We therefore believe that the “LDL-hypothesis” has been proven; the term appears to be outdated and should be replaced by “LDL causality”.

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