scholarly journals Bonabiline A, a Monoterpenoid 3α-Acyloxytropane from the Roots of Bonamia spectabilis showing M3 Receptor Antagonist Activity

Planta Medica ◽  
2013 ◽  
Vol 79 (06) ◽  
pp. 512-512 ◽  
Author(s):  
Sonja Ott ◽  
Kristina Jenett-Siems ◽  
Heinz Pertz ◽  
Karsten Siems ◽  
Ludger Witte ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Antagonist Activity ◽  
M3 Receptor

Bonabiline A, a Monoterpenoid 3α-Acyloxytropane from the Roots of Bonamia spectabilis showing M3 Receptor Antagonist Activity

Planta Medica ◽  
2006 ◽  
Vol 72 (15) ◽  
pp. 1403-1406 ◽  
Author(s):  
Sonja Ott ◽  
Kristina Jenett-Siems ◽  
Heinz Pertz ◽  
Karsten Siems ◽  
Ludger Witte† ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Antagonist Activity ◽  
M3 Receptor

M1 and M3 muscarinic antagonists inhibit human nasal glandular secretion in vitro

1992 ◽  
Vol 73 (5) ◽  
pp. 2069-2073 ◽  
Author(s):  
J. Mullol ◽  
J. N. Baraniuk ◽  
C. Logun ◽  
M. Merida ◽  
J. Hausfeld ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Muscarinic Receptor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Receptor Subtypes ◽  
Muscarinic Antagonists ◽  
Muscarinic Receptor Subtypes ◽  
Mucus Production ◽  
Glandular Secretion ◽  
M3 Receptor

Mucus glycoproteins (MGP) are high-molecular-weight glycoconjugates that are released from submucosal glands and epithelial goblet cells in the respiratory tract. Muscarinic receptors have an important role in the regulation of human nasal glandular secretion and mucus production, but it is not known which of the five muscarinic receptor subtypes are involved. The effect of nonselective and M1-, M2-, and M3-selective muscarinic antagonists on methacholine (MCh)-induced MGP secretion from human nasal mucosal explants was tested in vitro. MGP was assayed by enzyme-linked immunosorbent assay using a specific anti-MGP monoclonal antibody (7F10). MCh (100 microM) induced MGP secretion up to 127% compared with controls. MCh-induced MGP release was significantly inhibited by atropine (100 microM), the M, receptor antagonist pirenzepine (10–100 microM), and the M3 receptor antagonist 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP; 1–100 microM). 4-DAMP significantly inhibited MCh-induced MGP release at a lower concentration (1 microM) than pirenzepine (10 microM). The M2 receptor antagonists AF-DX 116 and gallamine (both at 100 microM) had no effect. No antagonist alone had a significant effect on MGP release. These results indicate that the M1 and M3 muscarinic receptor subtypes regulate MGP secretion from human nasal mucosa and suggest that the M3 receptor has the predominant effect.

Novel endomorphin-2 analogs with mu-opioid receptor antagonist activity

2005 ◽  
Vol 66 (3) ◽  
pp. 125-131 ◽  
Author(s):  
R. Kruszynski ◽  
J. Fichna ◽  
J.-C. do-Rego ◽  
N.N. Chung ◽  
P.W. Schiller ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Opioid Receptor ◽  
Mu Opioid Receptor ◽  
Antagonist Activity ◽  
Mu Opioid ◽  
Opioid Receptor Antagonist

ChemInform Abstract: Two Intermediates in the Synthesis of Decahydroisoquinolines with NMDA and AMPA Receptor Antagonist Activity.

ChemInform ◽  
2010 ◽  
Vol 33 (1) ◽  
pp. no-no
Author(s):  
J. Zukerman-Schpector ◽  
Mauricio Vega ◽  
I. Caracelli ◽  
Luiz C. Dias ◽  
Anna M. A. P. Fernandes
Keyword(s):  
Receptor Antagonist ◽  
Ampa Receptor ◽  
Antagonist Activity ◽  
Ampa Receptor Antagonist

scholarly journals In vitro H1-receptor antagonist activity of methanolic extract of tuber of Stephania glabra

2010 ◽  
Vol 5 (2) ◽  
Author(s):  
Nisar Ahmad Khan ◽  
Dinesh Kumar ◽  
Zulfiqar Ali Bhat ◽  
Vijender Kumar ◽  
Navneet Nagpal ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Methanolic Extract ◽  
H1 Receptor ◽  
Antagonist Activity ◽  
H1 Receptor Antagonist
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