Collagen analysis in aneurysmal ascending aorta obtained from patients with bicuspid aortic valve disease compared with tricuspid aortic valve aneurysm

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
A. Navarrete Santos ◽  
P. Lochmann ◽  
J.Y. Yan ◽  
A. Simm ◽  
R.-E. Silber ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Aortic Valve Disease ◽  
Ascending Aorta ◽  
Valve Disease ◽  
Tricuspid Aortic Valve ◽  
Collagen Analysis

Collagen analysis of the ascending aortic dilatation associated with bicuspid aortic valve disease compared with tricuspid aortic valve

2016 ◽  
Vol 122 (5) ◽  
pp. 289-294 ◽  
Author(s):  
Alexander Navarrete Santos ◽  
Junfeng Yan ◽  
Peter Lochmann ◽  
Heike Pfeil ◽  
Michael Petersen ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Aortic Valve Disease ◽  
Valve Disease ◽  
Aortic Dilatation ◽  
Tricuspid Aortic Valve ◽  
Collagen Analysis

Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease

2012 ◽  
Vol 28 (2) ◽  
pp. 268-275 ◽  
Author(s):  
Sergio Sciacca ◽  
Michele Pilato ◽  
Gianluigi Mazzoccoli ◽  
Valerio Pazienza ◽  
Manlio Vinciguerra
Keyword(s):  
Aortic Valve ◽  
Notch Signaling ◽  
Bicuspid Aortic Valve ◽  
Aortic Valve Disease ◽  
Ascending Aorta ◽  
Valve Disease ◽  
Longevity Gene

scholarly journals Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease?

2004 ◽  
Vol 128 (5) ◽  
pp. 677-683 ◽  
Author(s):  
Michael A. Borger ◽  
Mark Preston ◽  
Joan Ivanov ◽  
Paul W.M. Fedak ◽  
Piroze Davierwala ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Aortic Valve Disease ◽  
Ascending Aorta ◽  
Valve Disease

Management of the Ascending Aorta in Patients with Bicuspid Aortic Valve Disease

2008 ◽  
Vol 17 (5) ◽  
pp. 357-363 ◽  
Author(s):  
Michael P. Vallely ◽  
Christopher Semsarian ◽  
Paul G. Bannon
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Aortic Valve Disease ◽  
Ascending Aorta ◽  
Valve Disease

scholarly journals Impact of Mild Aortic Valve Disease on Late Outcomes after Replacement of the Ascending Aorta Case-control Study

2021 ◽  
Author(s):  
Ken Nakamura ◽  
Kouan Orii ◽  
Taichi Kondo ◽  
Mitsutaka Nakao ◽  
Makoto Wakatabe ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Aortic Valve Disease ◽  
Ascending Aorta ◽  
Valve Disease ◽  
Aortic Valve Area ◽  
Valve Regurgitation ◽  
Aortic Valve Regurgitation ◽  
Tricuspid Aortic Valve ◽  
Valve Area

Abstract Background: The time course of mild aortic valve disease after replacement of the ascending aorta is unclear. We sought to clarify it.Methods: Between January 2011 and December 2016, 26 patients (9 bicuspid and 17 tricuspid aortic valve disease) underwent replacement of the enlarged ascending aorta alone. We compared the postoperative disease course between bicuspid and tricuspid aortic valve by transthoracic echocardiography and computed tomography performed at 73 ± 23 and 60 ± 23 months post-surgery, respectively.Results: The bicuspid group was younger than the tricuspid group (62.1 ± 4.8 vs 73.3 ± 4.8 years). Pathophysiology predominantly involved aortic valve stenosis and regurgitation in the bicuspid and tricuspid group, respectively. The peak and mean pressure gradient increased (P = .16, and P = .46) and the aortic valve area decreased significantly in the bicuspid group (P = .005). Two patients in the bicuspid group who required re-operation had an aortic valve area of 1.2 cm2 at initial operation. Seventy percent of patients in the tricuspid group had less than mild aortic valve regurgitation preoperatively, which improved up to 82% at follow-up. Freedom from re-operation was 66.7% and 100% at 8 years for the bicuspid and tricuspid group, respectively. Conclusions: Aortic valve replacement may be considered for patients with bicuspid aortic valve stenosis if the aortic valve area is less than 1.2 cm2, even if the general diagnosis is mild aortic valve stenosis at initial surgery. Even mild aortic valve regurgitation may be improved by surgical intervention in the ascending aorta.

scholarly journals Seno-destructive smooth muscle cells in the ascending aorta of patients with bicuspid aortic valve disease

EBioMedicine ◽  
2019 ◽  
Vol 43 ◽  
pp. 54-66 ◽  
Author(s):  
Brittany Balint ◽  
Hao Yin ◽  
Zengxuan Nong ◽  
John-Michael Arpino ◽  
Caroline O'Neil ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Aortic Valve ◽  
Smooth Muscle Cells ◽  
Bicuspid Aortic Valve ◽  
Aortic Valve Disease ◽  
Muscle Cells ◽  
Ascending Aorta ◽  
Valve Disease
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