scholarly journals Seno-destructive smooth muscle cells in the ascending aorta of patients with bicuspid aortic valve disease

EBioMedicine ◽  
2019 ◽  
Vol 43 ◽  
pp. 54-66 ◽  
Author(s):  
Brittany Balint ◽  
Hao Yin ◽  
Zengxuan Nong ◽  
John-Michael Arpino ◽  
Caroline O'Neil ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Aortic Valve ◽  
Smooth Muscle Cells ◽  
Bicuspid Aortic Valve ◽  
Aortic Valve Disease ◽  
Muscle Cells ◽  
Ascending Aorta ◽  
Valve Disease

Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease

2012 ◽  
Vol 28 (2) ◽  
pp. 268-275 ◽  
Author(s):  
Sergio Sciacca ◽  
Michele Pilato ◽  
Gianluigi Mazzoccoli ◽  
Valerio Pazienza ◽  
Manlio Vinciguerra
Keyword(s):  
Aortic Valve ◽  
Notch Signaling ◽  
Bicuspid Aortic Valve ◽  
Aortic Valve Disease ◽  
Ascending Aorta ◽  
Valve Disease ◽  
Longevity Gene

scholarly journals Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease?

2004 ◽  
Vol 128 (5) ◽  
pp. 677-683 ◽  
Author(s):  
Michael A. Borger ◽  
Mark Preston ◽  
Joan Ivanov ◽  
Paul W.M. Fedak ◽  
Piroze Davierwala ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Aortic Valve Disease ◽  
Ascending Aorta ◽  
Valve Disease

Management of the Ascending Aorta in Patients with Bicuspid Aortic Valve Disease

2008 ◽  
Vol 17 (5) ◽  
pp. 357-363 ◽  
Author(s):  
Michael P. Vallely ◽  
Christopher Semsarian ◽  
Paul G. Bannon
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Aortic Valve Disease ◽  
Ascending Aorta ◽  
Valve Disease

Dynamically-Loaded 3-D Model to Study the ECM Organization of Aortic Smooth Muscle Cells in Aneurysmal Patients With Bicuspid Aortic Valve

2011 ◽  
Author(s):  
Wei He ◽  
Julie Phillippi ◽  
Christopher E. Miller ◽  
David A. Vorp ◽  
Thomas G. Gleason
Keyword(s):  
Smooth Muscle ◽  
Aortic Valve ◽  
Smooth Muscle Cells ◽  
Bicuspid Aortic Valve ◽  
Elective Surgery ◽  
Muscle Cells ◽  
The United States ◽  
Aortic Aneurysms ◽  
Aortic Replacement ◽  
Valvular Stenosis

Rupture of aortic aneurysms and dissections are the fifteenth leading cause of a death in the United States [1]. Over 40% of patients undergoing elective surgery for ascending aortic replacement due to thoracic aortic aneurysm (TAA) have a congenital defect in the aortic valve know as bicuspid aortic valve (BAV) [2]. BAV patients have uniformly larger diameter aortic roots and ascending aortas compared to age- and sex-matched controls [3] and abnormal elasticity even in the absence of valvular stenosis or aneurysm [4] and this greatly increases the risk of aortic dissection and sudden death [5]. The cause of TAA is uncertain, but recent studies suggest that oxidative stress may play a role in the pathogenesis of TAAs by degrading the extracellular matrix (ECM). We identified that BAV smooth muscle cells (SMCs) lack sufficient resistance to reactive oxygen species to maintain ECM homeostasis [6, 7].

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