Total Synthesis of Biselide A, A Cytotoxic Macrolide of Marine Origin

Synthesis ◽  
2017 ◽  
Vol 49 (13) ◽  
pp. 2958-2970 ◽  
Author(s):  
Ichiro Hayakawa ◽  
Hideo Kigoshi ◽  
Masami Okamura ◽  
Kazuaki Suzuki ◽  
Mami Shimanuki ◽  
...  
Keyword(s):  
Enzymatic Hydrolysis ◽  
Total Synthesis ◽  
Functional Group ◽  
Aldol Reaction ◽  
Oxygen Functional Group ◽  
Asymmetric Aldol ◽  
Marine Origin ◽  
Asymmetric Aldol Reaction ◽  
Cytotoxic Macrolide

The total synthesis of biselide A based on our earlier strategy of synthesizing haterumalides is reported. The highlights of this approach are the use of regioselective enzymatic hydrolysis for the installation of a C20 oxygen functional group and an asymmetric aldol reaction for the stereoselective introduction of a C3 oxygen functional group.

Total Synthesis of Aculeatins A and B, and Formal Synthesis of Aculeatin D and 6-epi-Aculeatin D through an Asymmetric Aldol Reaction

Synthesis ◽  
2015 ◽  
Vol 47 (09) ◽  
pp. 1303-1308
Author(s):  
Xiaoji Wang ◽  
Shuangping Huang ◽  
Shipeng Chen ◽  
Gaopeng Wang ◽  
Jianting Zhang ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Aldol Reaction ◽  
Asymmetric Aldol ◽  
Formal Synthesis ◽  
Asymmetric Aldol Reaction

ChemInform Abstract: Asymmetric Aldol Reaction of Dichloroacetaldehyde Catalyzed by Diarylprolinol.

ChemInform ◽  
2016 ◽  
Vol 47 (49) ◽  
Author(s):  
Yujiro Hayashi ◽  
Daichi Nakamura ◽  
Yusuke Yasui ◽  
Kotaro Iwasaki ◽  
Hiroaki Chiba
Keyword(s):  
Aldol Reaction ◽  
Asymmetric Aldol ◽  
Asymmetric Aldol Reaction

An Improved Protocol for the Direct Asymmetric Aldol Reaction in Ionic Liquids, Catalysed by Onium Ion-Tagged Prolines

2007 ◽  
Vol 349 (11-12) ◽  
pp. 2061-2065 ◽  
Author(s):  
Marco Lombardo ◽  
Filippo Pasi ◽  
Srinivasan Easwar ◽  
Claudio Trombini
Keyword(s):  
Ionic Liquids ◽  
Aldol Reaction ◽  
Asymmetric Aldol ◽  
Asymmetric Aldol Reaction
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