Application of Trimethylsilanolate Alkali Salts in Organic Synthesis

Trimethylsilanolate alkali salts are widely used in organic synthesis, mainly due to their solubility in common organic solvents. They are frequently used as nucleophiles in ester hydrolysis, both in solution and solid-phase chemistry. However, they have also been used as mild bases or as specific reagents in some chemical transformations. Reactions employing trimethylsilanolate alkali salts as the key component are typically performed under mild reaction conditions. This review summarizes the utilization of trimethylsilanolate alkali salts in various organic transformations.1 Introduction2 Properties of Alkali Metal Trimethylsilanolates (TMSO[M])3 Trimethylsilanolate Alkali Salts in Organic Synthesis4 Conclusion

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Site-Targeted Interfacial Solid-Phase Chemistry: Surface Functionalization of Organic Monolayers via Chemical Transformations Locally Induced at the Boundary between Two Solids

Angewandte Chemie ◽

10.1002/ange.201604973 ◽

2016 ◽

Vol 128 (40) ◽

pp. 12554-12559

Author(s):

Rivka Maoz ◽

Doron Burshtain ◽

Hagai Cohen ◽

Peter Nelson ◽

Jonathan Berson ◽

...

Keyword(s):

Surface Functionalization ◽

Solid Phase ◽

Chemical Transformations ◽

Organic Monolayers ◽

Phase Chemistry ◽

Solid Phase Chemistry

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Solid-Phase Chemistry: Linkers for Solid-Phase Organic Synthesis (SPOS) and Combinatorial Approaches on Solid Support

ChemInform ◽

10.1002/chin.200309244 ◽

2003 ◽

Vol 34 (9) ◽

Author(s):

Willi Bannwarth

Keyword(s):

Organic Synthesis ◽

Solid Phase ◽

Solid Support ◽

Solid Phase Organic Synthesis ◽

Phase Chemistry ◽

Solid Phase Chemistry

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Site-Targeted Interfacial Solid-Phase Chemistry: Surface Functionalization of Organic Monolayers via Chemical Transformations Locally Induced at the Boundary between Two Solids

Angewandte Chemie International Edition ◽

10.1002/anie.201604973 ◽

2016 ◽

Vol 55 (40) ◽

pp. 12366-12371 ◽

Cited By ~ 4

Author(s):

Rivka Maoz ◽

Doron Burshtain ◽

Hagai Cohen ◽

Peter Nelson ◽

Jonathan Berson ◽

...

Keyword(s):

Surface Functionalization ◽

Solid Phase ◽

Chemical Transformations ◽

Organic Monolayers ◽

Phase Chemistry ◽

Solid Phase Chemistry

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Facile synthesis of artificial enzyme nano-environments via solid-phase chemistry of immobilized derivatives: Dramatic stabilization of penicillin acylase versus organic solvents

Enzyme and Microbial Technology ◽

10.1016/s0141-0229(98)00102-1 ◽

1999 ◽

Vol 24 (1-2) ◽

pp. 96-103 ◽

Cited By ~ 76

Author(s):

R. Fernandez-Lafuente ◽

C.M. Rosell ◽

L. Caanan-Haden ◽

L. Rodes ◽

J.M. Guisan

Keyword(s):

Organic Solvents ◽

Solid Phase ◽

Penicillin Acylase ◽

Artificial Enzyme ◽

Facile Synthesis ◽

Phase Chemistry ◽

Solid Phase Chemistry

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Recent Application of Polystyrene-supported Triphenylphosphine in Solid-Phase Organic Synthesis

Current Organic Chemistry ◽

10.2174/1385272822666181026115752 ◽

2019 ◽

Vol 23 (6) ◽

pp. 643-678

Author(s):

Lalthazuala Rokhum ◽

Ghanashyam Bez

Keyword(s):

Organic Synthesis ◽

Combinatorial Chemistry ◽

Solid Phase ◽

Recent Application ◽

Organic Transformations ◽

Solid Phase Organic Synthesis ◽

Wide Range ◽

Fast Development ◽

Polymer Supported

Recent years have witnessed a fast development of solid phase synthetic pathways, a variety of solid-supported reagent and its applications in diverse synthetic strategies and pharmaceutical applicability’s. Polymer-supported triphenylphosphine is getting a lot of applications owing to the speed and simplicity in the process. Furthermore, ease of recyclability and reuse of polymer-supported triphenylphosphine added its advantages. This review covers a wide range of useful organic transformations which are accomplished using cross-linked polystyrene-supported triphenylphosphine with the aim of giving renewed interest in the field of organic and medicinal-combinatorial chemistry.

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