Metal-free Deamidative Ugi Access to Isoindolinones

Synlett ◽  
2018 ◽  
Vol 29 (14) ◽  
pp. 1842-1846 ◽  
Author(s):  
Lamouri Hammal ◽  
Laurent El Kaïm ◽  
Samira Baaziz ◽  
Mansour Kerim ◽  
Marie Cordier
Keyword(s):  
Nucleophilic Substitution ◽  
Aromatic Aldehydes ◽  
Oxidative Process ◽  
Metal Free ◽  
Amido Group ◽  
Vicarious Nucleophilic Substitution ◽  
Nitrobenzoic Acid

A two-step isoindolone synthesis has been achieved by using an Ugi/oxidative vicarious nucleophilic substitution sequence starting from 3-nitrobenzoic acid and aromatic aldehydes. Loss of the amido group was observed as well as a further oxidative process towards hydroxyisoindolone derivatives after prolonged stirring open to the atmosphere.

Synthesis of 2-Aryl-5-alkyl-fulleropyrrolidines: Metal-Free-Mediated Reaction of [60]Fullerene with Aromatic Aldehydes and Inactive Primary Amines

2017 ◽  
Vol 82 (16) ◽  
pp. 8617-8627 ◽  
Author(s):  
Meng Zhang ◽  
Hui-Juan Wang ◽  
Fa-Bao Li ◽  
Xin-Xin Zhong ◽  
Yong-Shun Huang ◽  
...  
Keyword(s):  
Aromatic Aldehydes ◽  
Primary Amines ◽  
Metal Free

ChemInform Abstract: Asymmetric Aromatic Vicarious Nucleophilic Substitution of Hydrogen.

ChemInform ◽  
2010 ◽  
Vol 28 (23) ◽  
pp. no-no
Author(s):  
M. D. DREW ◽  
D. A. JACKSON ◽  
N. J. LAWRENCE ◽  
J. LIDDLE ◽  
R. G. PRITCHARD
Keyword(s):  
Nucleophilic Substitution ◽  
Nucleophilic Substitution Of Hydrogen ◽  
Vicarious Nucleophilic Substitution
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