Prospective Analysis after Coronary-artery Bypass Grafting: Platelet GP IIIa Polymorphism (HPA-1b /PlA2) Is a Risk Factor for Bypass Occlusion, Myocardial Infarction, and Death

2000 ◽  
Vol 83 (03) ◽  
pp. 404-407 ◽  
Author(s):  
Michael Klein ◽  
Hans Dauben ◽  
Christiane Moser ◽  
Emmeran Gams ◽  
Rüdiger Scharf ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Odds Ratio ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Hereditary Risk ◽  
Artery Disease

SummaryRecently, we have demonstrated that human platelet antigen 1b (HPA-1b or PlA2) is a hereditary risk factor for platelet thrombogenicity leading to premature myocardial infarction in preexisting coronary artery disease. However, HPA-1b does not represent a risk factor for coronary artery disease itself. The aim of our present study was to evaluate the role of HPA-1b on the outcome in patients after coronaryartery bypass surgery. We prospectively determined the HPA-1 genotype in 261 consecutive patients prior to saphenous-vein coronaryartery bypass grafting. The patients were followed for one year. Among patients with bypass occlusion, myocardial infarction, or death more than 30 days after surgery, the prevalence of HPA-1b was significantly higher than among patients without postoperative complications (60 percent, 6/10, vs. 24 percent, 58/241, p <0.05, odds ratio 4.7). Using a stepwise logistic regression analysis with the variables HPA1b, age, sex, body mass index, smoking (pack-years), hypertension, diabetes, cholesterol and triglyceride concentration, only HPA-1b had a significant association with bypass occlusion, myocardial infarction, or death after bypass surgery (p = 0.019, odds ratio 4.7). This study shows that HPA-1b is a hereditary risk factor for bypass occlusion, myocardial infarction, or death in patients after coronary-artery bypass surgery.

No Association between the 20210 G/A Prothrombin Gene Mutation and Premature Coronary Artery Disease

1998 ◽  
Vol 80 (12) ◽  
pp. 878-880 ◽  
Author(s):  
J. W. Eikelboom ◽  
R. Parsons ◽  
R. R. Taylor ◽  
F. M. van Bockxmeer ◽  
R. I. Baker
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Gene Mutation ◽  
Odds Ratio ◽  
Premature Coronary Artery Disease ◽  
Prothrombin Gene Mutation ◽  
Prothrombin Gene ◽  
Artery Disease

SummaryThe 20210 G/A prothrombin gene mutation is associated with an increased risk of venous thrombosis but whether there is an association of the mutation with premature coronary artery disease and acute myocardial infarction remains unclear.To further assess the role of the G/A genotype as a risk factor for arterial vascular disease, we performed a case-control study of 644 patients aged less than 50 years with angiographically proven coronary artery disease, 402 of whom had myocardial infarction, and 679 unrelated healthy control subjects aged less than 50 years, randomly selected from the electoral roll.The prevalence of the G/A genotype was 2.5% in patients with coronary artery disease, and 3.2% in control subjects (odds ratio 0.8; 95% confidence interval 0.35 to 1.83). The mutation was not more frequent among patients with a history of myocardial infarction (2.2%, odds ratio 0.7; 95% confidence interval 0.27 to 2.05), and there was no evidence of an interaction between the prothrombin mutation and conventional cardiovascular disease risk factors. There was no association between genotype and extent of angiographic coronary artery disease (p = 0.73).We conclude that the 20210 G/A prothrombin gene mutation is not a major risk factor for premature coronary artery disease in our predominantly Caucasian Australian population.

Angioplasty in the management of coronary artery disease

1993 ◽  
Vol 31 (12) ◽  
pp. 45-47
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Artery Bypass ◽  
Percutaneous Transluminal Coronary Angioplasty ◽  
Bypass Grafting ◽  
Artery Disease ◽  
The Uk ◽  
Transluminal Coronary Angioplasty ◽  
Percutaneous Transluminal

In 1990 nearly 8500 patients with coronary artery disease in the UK were treated with percutaneous transluminal coronary angioplasty (PTCA)1 and the number is steadily increasing. In this article we discuss the use of PTCA for the treatment of patients with angina pectoris or acute myocardial infarction, and compare it with coronary artery bypass grafting (CABG).

Predictors of atrial dysrhythmias for patients undergoing coronary artery bypass grafting

2000 ◽  
Vol 9 (6) ◽  
pp. 388-396 ◽  
Author(s):  
MJ De Jong ◽  
PG Morton
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Right Coronary Artery ◽  
Odds Ratio ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Artery Bypass Grafting ◽  
Artery Disease

BACKGROUND: Coronary artery bypass grafting is a commonly used and effective procedure for treating coronary artery disease. Atrial dysrhythmias are common after this surgery, but definitive characteristics that predict the development of such dysrhythmias postoperatively have not been determined. OBJECTIVES: To determine demographic, preoperative, intraoperative, and postoperative factors that are predictive of atrial dysrhythmias that occur after coronary artery bypass grafting. METHODS: A descriptive design was used to study a convenience sample (N = 162) of adult patients undergoing coronary artery bypass grafting. Data were collected via prospective chart review. Patients were grouped according to whether or not atrial dysrhythmias developed after coronary artery bypass grafting. Univariate analyses followed by multivariate analyses were conducted by using forward stepwise logistic regression to determine variables that are predictive of atrial dysrhythmias after coronary artery bypass grafting. RESULTS: Postoperative atrial dysrhythmias developed in 52 patients (32.1%). Univariate predictors of postoperative atrial dysrhythmias included older age (P &lt; .001) and presence of right coronary artery disease (P = .004). Multivariate predictors of postoperative atrial dysrhythmias included age (odds ratio by decade = 1.93, 95% CI = 1.86-2.00, P &lt; .001) and right coronary artery disease (odds ratio = 2.67, 95% CI = 1.14-6.23, P = .02). Hospital stay was significantly longer (P = .003) in patients who had postoperative atrial dysrhythmias than in patients who did have these dysrhythmias. CONCLUSIONS: Age and right coronary artery disease can be used to predict which patients will be at increased risk for atrial dysrhythmias after coronary artery bypass grafting.

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