scholarly journals Menière's Disease and Disorders of the Carbohydrate Metabolism Involving the Inner Ear

2019 ◽  
Vol 23 (02) ◽  
pp. 218-220
Author(s):  
Pedro L. Mangabeira Albernaz
Keyword(s):  
Inner Ear ◽  
Carbohydrate Metabolism ◽  
Endolymphatic Hydrops ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Delayed Endolymphatic Hydrops ◽  
Ménière's Disease

Introduction Menière’s disease was described in 1861, but there are still uncertainties regarding its pathophysiology and treatment. Endolymphatic hydrops is recognized as a fundamental pathological characteristic of the disease, as a result of an inadequate absorption of the endolymph. A milder type of endolymphatic hydrops results from an altered chemical composition of the endolymph, due to disorders of the carbohydrate metabolism. Objective To describe the association of both types of hydrops in patients with Menière disease. Methods This was a retrospective study of 98 patients with Menière’s disease, 62 of whom also presented disorders of the carbohydrate metabolism, and 5 patients with delayed endolymphatic hydrops, 2 of whom also presented disorders of the carbohydrate metabolism. Results The follow-up of these patients showed that the correction of the metabolic disorders may help in the clinical treatment of Menière’s disease and of delayed endolymphatic hydrops, but this does not happen in the more severe types of the diseases. Conclusion Patients with Menière’s disease may present simultaneous disorders of the carbohydrate metabolism, affecting the inner ear. The correction of these disorders helps the clinical treatment but does not preclude the progression of the more severe cases of Menière disease.

Primary Intravestibular Lipoma

1989 ◽  
Vol 98 (5) ◽  
pp. 393-395 ◽  
Author(s):  
Tsun-Sheng Huang
Keyword(s):  
Inner Ear ◽  
Endolymphatic Hydrops ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Delayed Endolymphatic Hydrops ◽  
Ménière's Disease ◽  
Unusual Symptoms

An intravestibular lipoma was discovered during destructive surgery for disabling vertigo in a case diagnosed as delayed endolymphatic hydrops. The author recommends that in cases that resemble Meniere's disease but have unusual symptoms, the existence of other lesions within the inner ear should be suspected.

scholarly journals Endolymphatic Hydrops in Patients With Vestibular Migraine and Concurrent Meniere's Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Sun-Young Oh ◽  
Marianne Dieterich ◽  
Bit Na Lee ◽  
Rainer Boegle ◽  
Jin-Ju Kang ◽  
...  
Keyword(s):  
Inner Ear ◽  
Endolymphatic Hydrops ◽  
Meniere’S Disease ◽  
Vestibular Migraine ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Volumetric Quantification ◽  
Ménière's Disease

Objective: Intravenous contrast agent enhanced, high-resolution magnetic resonance imaging of the inner ear (iMRI) confirmed that patients with Menière's disease (MD) and vestibular migraine (VM) could present with endolymphatic hydrops (EH). The present study aimed to investigate EH characteristics and their interrelation to neurotologic testing in patients with VM, MD, or VM with concurrent MD (VM-MD).Methods: Sixty–two patients (45 females, aged 23–81 years) with definite or probable VM (n = 25, 19 definite), MD (n = 29, 17 definite), or showing characteristics of both diseases (n = 8) were included in this study. Diagnostic workup included neurotologic assessments including video-oculography (VOG) during caloric stimulation and head-impulse test (HIT), ocular and cervical vestibular evoked myogenic potentials (o/cVEMP), pure tone audiometry (PTA), as well as iMRI. EH's degree was assessed visually and via volumetric quantification using a probabilistic atlas-based segmentation of the bony labyrinth and volumetric local thresholding (VOLT).Results: Although a relevant number of VM patients reported varying auditory symptoms (13 of 25, 52.0%), EH in VM was only observed twice. In contrast, EH in VM-MD was prevalent (2/8, 25%) and in MD frequent [23/29, 79.3%; χ2(2) = 29.1, p < 0.001, φ = 0.7]. Location and laterality of EH and neurophysiological testing classifications were highly associated (Fisher exact test, p < 0.005). In MD, visual semi-quantitative grading and volumetric quantification correlated highly to each other (rS = 0.8, p < 0.005, two-sided) and to side differences in VOG during caloric irrigation (vestibular EH ipsilateral: rS = 0.6, p < 0.05, two-sided). In VM, correlations were less pronounced. VM-MD assumed an intermediate position between VM and MD.Conclusion: Cochlear and vestibular hydrops can occur in MD and VM patients with auditory symptoms; this suggests inner ear damage irrespective of the diagnosis of MD or VM. The EH grades often correlated with auditory symptoms such as hearing impairment and tinnitus. Further research is required to uncover whether migraine is one causative factor of EH or whether EH in VM patients with auditory symptoms suggests an additional pathology due to MD.

scholarly journals MENIERE’S DISEASE

2021 ◽  
Vol 2 (1) ◽  
pp. 18-21
Author(s):  
Helena Era Millennie ◽  
Badrul Munir ◽  
Zamroni Afif ◽  
Ria Damayanti ◽  
Shahdevi Nandar Kurniawan
Keyword(s):  
Inner Ear ◽  
Endolymphatic Hydrops ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Vestibular Evoked Myogenic Potentials ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Episodic Vertigo ◽  
Ménière's Disease

Meniere’s disease is a disorder of the inner ear resulting in symptoms of episodic vertigo, tinnitus, hearing loss and aural pressure. Although the exact etiology is uncertain, it is associated with raised pressure in the endolymph of the inner ear (endolymphatic hydrops). The diagnosis of Meniere's disease is based on the clinical setting of the patient. This disease usually presents with unilateral ear symptoms but can be also bilateral. Meniere's disease attacks are usually random and episodic (approximately 6-11 per year), with periods of remission that can last from months to years. Investigations are audiometry, electronystagmogram, vestibular evoked myogenic potentials (VEMPs) and imaging.The management consist pharmacological and non pharmacological. Meniere's disease is initially progressive but fluctuates unexpectedly. It is difficult to distinguish natural resolutions from treatment effects.

Fully automated analytic system for measuring endolymphatic hydrops ratio in Ménière's disease using deep learning and MRI (Preprint)

2021 ◽  
Author(s):  
Chae Jung Park ◽  
Young Sang Cho ◽  
Myung Jin Chung ◽  
Yi-Kyung Kim ◽  
Hyung-Jin Kim ◽  
...  
Keyword(s):  
Inner Ear ◽  
Endolymphatic Hydrops ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Mr Images ◽  
Menière's Disease ◽  
Ménière's Disease ◽  
Analysis System

BACKGROUND Recently, analysis of endolymphatic hydrops (EH) using inner ear magnetic resonance imaging (MRI) in Ménière's disease (MD) has been attempted in various studies. In addition, artificial intelligence (AI) has rapidly been incorporated into the medical field. In our previous study, the automated analysis algorithm of EH was completed using the convolutional neural network (CNN). However, several limitations existed, and further studies were conducted to compensate for these limitations. OBJECTIVE The aim of this study is to develop a fully automated analytic system for measuring endolymphatic hydrops, which provides enhanced analysis accuracy and clinical usability in studying Ménière's disease with MRI. METHODS We propose 3into3Inception and 3intoUNet, whose network architectures are based on Inception-v3 and U-Net, respectively. The developed networks were trained for inner ear segmentation using magnetic resonance (MR) images of 124 people and were embedded in a new automated EH analysis system, INner ear Hydrops Estimation via ARtificial InTelligence - version 2 (INHEARIT-v2). After 5-fold cross-validation, an additional test was performed using 60 new unseen MR images to evaluate the performance of our system. INHEARIT-v2 has a new functionality to automatically select representative images from a full MR stack. RESULTS The average segmentation performances of 5-fold cross-validation were measured by the intersection of union, which showed 0.743 ± 0.030 for 3into3Inception and 0.781 ± 0.030 for 3intoUNet. The automatic representative slice selection results of the INHEARIT-v2 differed only within two slices from the expert selection on an unseen dataset. Compared with the ratio measured by experienced physicians, the average interclass correlation coefficient (ICC) for all cases was 0.941; the average ICC of the vestibules was 0.968, and that of cochleae was 0.914. The time required for the fully automated system to accurately analyze the EH ratio in one patient's MRI stack was approximately 3.5 seconds. CONCLUSIONS In this study, a fully automated full-stack MR analysis system of the EH ratio was developed, named INHEARIT-v2, which showed high agreement with experts in an additional test. The system is an upgraded version of INHEARIT and provides higher segmentation performance and includes automatic representative image selection in the MR stack. The new model can help clinicians by providing an objective analysis result and reduce their workload in reading MRIs.

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