Green One-Pot Asymmetric Synthesis of Peptidomimetics via Sequential Organocatalyzed Aziridination and Passerini Multicomponent Reaction
Keyword(s):
One Pot
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Peptidomimetics containing an aziridine moiety have been reported as potent cysteine protease inhibitors. In this sense, the development of stereoselective and sustainable synthetic strategies to obtain three-membered N-heterocyclic compounds has gained importance in the last decades. In this work, an efficient method was designed to achieve highly functionalized aziridine peptidomimetics via a sequential reaction, which involves the organocatalytic aziridination of α,β-unsaturated aldehydes followed by the Passerini multicomponent reaction in an environmentally friendly solvent mixture (ethanol: water).
2013 ◽
Vol 13
(7)
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pp. 988-996
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1991 ◽
Vol 26
(2)
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pp. 113-124
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2007 ◽
Vol 15
(15)
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pp. 5340-5350
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2000 ◽
Vol 74
(10)
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pp. 4894-4897
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2017 ◽
Vol 27
(22)
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pp. 5031-5035
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