Giant Cell Tumor of Triquetrum: A Case Report with Literature Review

Author(s):  
Mohammed T. Ansari ◽  
Vijay K. Digge ◽  
Asjad Mahmood

Abstract Background Giant cell tumor (GCT) of bone is a benign, aggressive tumor of bone and occurs commonly around the knee and distal radius. GCT of bone rarely occurs in hand. In hand, metacarpals are the most common site and there have been only a few case reports of GCT of the carpal bone. In hand, these tumors are very aggressive and these have a high tendency to recur after intralesional curettage. No long-term study is available for choosing an appropriate method of treatment for these tumors in hand. Case Description Herein, we report a case of GCT of the bone involving triquetrum which was managed by excision of triquetrum and scaphoid bone. The reconstruction of the wrist was done through limited carpal fusion, by doing three corner fusion of the wrist. At 2 years after surgery, the patient was asymptomatic and radiographs revealed fusion of lunocapitate and lunohamate joints with no evidence of recurrence. Literature review Current literature regarding GCT of triquetrum includes case reports that are reviewed in this report. Clinical Relevance This case illustrates the successful treatment of GCT of triquetrum, which is a rare tumor. Three-corner fusion is a reliable and reproducible procedure that has been used for other arthritic conditions. The use of three corner fusion procedure can be extended to GCT of carpal bones. It has been a motion-preserving alternative to proximal row carpectomy (PRC).

2017 ◽  
Vol 43 (1) ◽  
Author(s):  
Samvel Bardakhchyan ◽  
Leo Kager ◽  
Samvel Danielyan ◽  
Armen Avagyan ◽  
Nerses Karamyan ◽  
...  

2013 ◽  
Vol 7 (1) ◽  
pp. 103-108 ◽  
Author(s):  
Theresa J.C Pazionis ◽  
Hussain Alradwan ◽  
Benjamin M Deheshi ◽  
Robert Turcotte ◽  
Forough Farrokhyar ◽  
...  

Introduction: Surgical management of Giant Cell Tumor of Bone of the distal radius (GCTDR) remains controversial due to risk of local recurrence (LR) offset by functional limitations which result from en-bloc resection. This study aims to determine the oncologic and functional outcomes of wide excision (WE) vs intralesional curettage (IC) of GCTDR. Methods: A complete search of the applicable literature was done. Included studies reported on patients from the same cohort who were surgically treated for GCTDR with WE or IC. Two reviewers independently assessed all papers. The primary outcome measure was LR. Results: One-hundred-forty-one patients from six studies were included: 60 treated with WE, and 81 with IC. Five WE patients (8%) suffered LR whereas 25 IC patients (31%) did. The odds of LR were three times less in the WE group vs the IC group. MSTS1993 scores, where available, were on average 'good' with WE and 'excellent' with IC. Conclusions: Within statistical limitations the data support an attempt, where feasible, at wrist joint preservation and superior function with IC. Intralesional curettage is reasonable when the functional benefit outweighs the risk of recurrence as is the case in many cases of GCT of the distal radius.


Cureus ◽  
2021 ◽  
Author(s):  
Cihan Kadipasaoglu ◽  
Andrew Wahba ◽  
Meenakshi B Bhattacharjee ◽  
Branko Cuglievan ◽  
Stephen A Fletcher

2021 ◽  
Author(s):  
taojun gong ◽  
Yi Luo ◽  
Yitian Wang ◽  
Chuanxi Zheng ◽  
Jianguo Fang ◽  
...  

Abstract Background: Giant cell tumor of bone (GCTB) is a rare benign but locally aggressive bone tumor. It has a high tendency for local recurrence, which may increase the occurrence of lung metastasis. Currently, the treatment of pulmonary metastases of GCTB is controversial. Denosumab is the preferred regimen for unresectable metastatic lesions, but there are no alternative treatment options when denosumab is resistant. So far, no case reports of metastatic GCTB treated with denosumab and apatinib have been published. Case presentation: This is a case report of a 26-year-old female who experienced right knee pain for over 6 months. Radiography and computed tomography revealed osteolytic bony destruction in the proximal right tibia. Using histological, radiological, and clinical techniques, a diagnosis of GCTB was achieved. Meanwhile, the immunohistochemical stain-identified the tumor cells were positive for vascular endothelial growth factor receptor 2 (VEGFR-2). After intralesional curettage of the primary tumor and wide resection of local recurrence surgeries, she developed recurrent hemoptysis. Chest computed tomography (CT) images showed multiple pulmonary nodules. She was administrated denosumab therapy but disease progression was confirmed after four months of treatment. She then received denosumab and apatinib therapy for 24 months, after a partial response was achieved.Conclusions: We depict a case of multiple pulmonary metastases of GCTB successfully controlled by denosumab and apatinib therapy. VEGFR-2 may be an effective therapeutic target for GCTB with pulmonary metastasis when denosumab is ineffective.


2007 ◽  
Vol 7 (4) ◽  
pp. 499-505 ◽  
Author(s):  
Yoichi Shimada ◽  
Michio Hongo ◽  
Naohisa Miyakoshi ◽  
Yuji Kasukawa ◽  
Shigeru Ando ◽  
...  

2016 ◽  
Vol 32 (5) ◽  
pp. 873-876 ◽  
Author(s):  
Loic Sigwalt ◽  
Emeline Bourgeois ◽  
Ahmad Eid ◽  
Chantal Durand ◽  
Jacques Griffet ◽  
...  

2016 ◽  
Vol 35 (11) ◽  
pp. 385-388 ◽  
Author(s):  
Debajyoti Chatterjee ◽  
Kirti Gupta ◽  
Navneet Singla ◽  
Ankur Kapoor

Sign in / Sign up

Export Citation Format

Share Document