Alagille Syndrome: A case report of a rare oral and multisystem manifestation

Alagille syndrome is an inherited multisystem disorder of autosomal dominant transmission. Its prevalence is estimated at 1 per 70,000 to 100,000 live births. We report the case of a young patient suffering from Alagille syndrome who consulted the center of diagnosis and dental treatment of Rabat - MOROCCO (CCTD). The general manifestations are facial dysmorphia, hepatic, cardiac, and ocular disorders. Hepatic cholestasis causes oral repercussions such as a yellow oral mucosa, hypomineralization of the teeth, and a high tendency to dental caries. The management of such a patient requires the knowledge of the general health of the patient, therefore collaboration with the attending physicians, the establishment of rigorous oral hygiene, personalized prophylaxis with a consequent contribution of fluorine.

derivative on the value relevance through tax avoidance and earnings control

This investigation expects to inspect and analyze the effect of derivative transactions on earnings management, the role of corporate tax avoidance in moderating effect of derivative transactions on earnings management, the effect of earnings management worth pertinence of earnings, and the effect of derivative transactions Worth Pertinence of earnings. This examination utilizes information from non-monetary organizations in Indonesia and Thailand for the period 2013-2017 with 91 test of organizations. This investigation, earnings management is calculated based on the Jaggi model and the Jaggi changed model. The value relevance of earnings is calculated based on Ohlson's model. Corporate tax avoidance is calculated based on the book tax difference. The results show that subordinate exchanges have a constructive outcome on earnings management. Corporate tax avoidance has not been proven to strengthen the effect of derivative transactions on earnings management. Earnings management adversely influences the worth pertinence of earnings. Derivative transactions negatively affect the value relevance of earnings. Derivative transactions, especially those with non-hedging criteria, show a high tendency towards earnings management activities. Intercountry testing, derivative transactions have a positive effect on earnings management in Indonesia while in Thailand it does not.

Ionic Liquid Additives in Water-Based Lubricants for Bearing Steel – Effect of Electrical Conductivity and pH on Surface Chemistry, Friction and Wear

Water-based lubricants have the potential to become the largest environmentally friendly lubricants in applications such as electric vehicles and the newly emerging green technologies of the future due to their inherent low viscosity and cooling properties. In order to be environmentally acceptable (EAL), both base lubricants and additives should comply with biodegradability, non-toxicity, and non-bioaccumulation requirements. Additives for water-based lubricants should ideally be polar and soluble in water and, at the same time, should not increase the electrical conductivity to critical levels for corrosion. However, most additives used in synthetic or mineral oils are non-polar. Ionic liquids have recently gained attention as lubricant additives due to their high polarity, making them highly surface-active (i.e. high tendency to adsorb on metal surfaces). However, they are seen as highly corrosive for many metal alloys. In this work, a water-glycol lubricant containing two different ionic liquids has been investigated as a potential green lubricant for a bearing steel AISI 52100 with accurate control on electrical conductivity and pH. The selected ionic liquids were tributylmethylphosphonium dimethylphosphate (PP) and 1-butyl-1-methylpyrrolidinium tris(pentafluoroethyl)trifluorophosphate (BMP). The tribological behaviour of the ionic liquids was compared with a well-known organic friction modifier, dodecanoic acid (C12). The ionic liquids showed lower friction and wear rate than the water-based lubricant alone. However, they showed higher friction than the lubricant formulated with C12, in which PP gave lower friction than BMP due to low pH. A detailed subsurface analysis of the wear track using scanning-transmission electron microscopy (STEM) showed that a thick oxide tribofilm was built on the wear track for both lubricants formulated with ionic liquids due to high electrical conductivity. This tribofilm gave beneficial effect on wear. Although PP and BMP gave thicker tribofilms than C12, it was not durable, resulting in cracking and detachment.

Extracellular Vesicles from Carcinoma-Associated Fibroblasts Promote Epithelial-Mesenchymal Transition of Salivary Adenoid Cystic Carcinoma via Interleukin-6

Carcinoma-associated fibroblasts (CAF) play a pivotal role in cancer progression. Salivary adenoid cystic carcinoma (SACC) has a high tendency to invade and metastasize. Understanding how CAF interact with SACC cells is essential to develop new targeting therapies for SACC. Extracellular vesicles (EVs) play important roles in intercellular communication. However, the role of CAF-derived EVs in SACC invasion remains poorly understood. In this study, we show that CAF EVs promote the migration and invasion abilities of SACC cells. The expression of biomarkers of epithelial-mesenchymal transition (EMT) was higher in SACC cells treated with CAF EVs treated with CAF EVs than in the negative controls, and high levels of IL-6 were detected in CAF and their EVs. Knockdown of IL-6 in CAF decreased invasive abilities and EMT biomarker expression in SACC cells induced by CAF EVs. CAF EV-associated IL6 promoted SACC EMT by activating JAK2/STAT3 signaling pathway. These findings suggest that targeting CAF-derived EVs may be an effective strategy for inhibiting SACC invasion.

Interaction of Th(IV), Pu(IV) and Fe(III) with ferritin protein: how similar?

Ferritin is the main protein of Fe storage in eukaryote and prokaryote cells. It is a large multifunctional, multi-subunit protein consisting of heavy H and light L subunits. In the field of nuclear toxicology, it has been suggested that some actinide elements, such as thorium and plutonium at oxidation state +IV, have a comparable `biochemistry' to iron at oxidation state +III owing to their very high tendency for hydrolysis and somewhat comparable ionic radii. Therefore, the possible mechanisms of interaction of such actinide elements with the Fe storage protein is a fundamental question of bio-actinidic chemistry. We recently described the complexation of Pu(IV) and Th(IV) with horse spleen ferritin (composed mainly of L subunits). In this article, we bring another viewpoint to this question by further combining modeling with our previous EXAFS data for Pu(IV) and Th(IV). As a result, the interaction between the L subunits and both actinides appears to be non-specific but driven only by the density of the presence of Asp and Glu residues on the protein shell. The formation of an oxyhydroxide Th or Pu core has not been observed under the experimental conditions here, nor the interaction of Th or Pu with the ferric oxyhydroxide core.

The Study of Developing a Financial Literacy Scale for University Students in the Digital Era

Financial literacy, in its shortest definition, is the ability of individuals to use money rationally. Today, young individuals' infrastructure and kits are not enough to understand finance and make the right decisions in the modern financial world. It is extremely essential for young university students to have sufficient financial literacy in order to have a high tendency to consume and to be individuals who will go into business life in the near future. In this study, the authors conduct a scale study to measure the financial literacy levels of undergraduate students and its relation to the digital environment in the 2020-2021 academic year. The scale consists of three factors under the headings of financial information, financial prudence, and borrowing attitude, and 20 sub-items. In the study, the authors also compare the financial literacy variable with sociodemographic, socioeconomic, and descriptive variables by using t-test and ANOVA analysis. The findings show that there are no significant differences among undergraduate students.

Dye Contaminated Waste Water Treatment through Metal-Organic Frameworks (MOFs) based Materials

The high tendency of water to get polluted is due to the extensive usability among all the resources. Amongst all the anthropogenic pollutants, a variety of synthetic non-biodegradable dyestuff are...

A Novel NIR-II Theranostic Agent: A Win–win Strategy of Tracing and Blocking Tumor-associated Vessels for Oral Squamous Cell Carcinoma

Tumor vessel co-option is a crucial predictor for tumor invasiveness but is easy to ignore in tumor vascular targeting therapy. A high density of tumor vessel co-option located alongside the tumor frontier predicted a high tendency of tumor invasion and regional metastasis. Herein, a novel NIR-II nanoagent (CS NPs) was constructed with an organic COi8DFIC dye and sorafenib, which demonstrated high tissue penetration and low tissue autofluorescence, enabling imaging of vessel co-option and tumor micrometastasis. This nanotherapeutic agent displayed considerably improved quantum yield of fluorescence (0.89%), high ROS generation and fairly good biosafety in vivo. Compared with indocyanine green (ICG), CS NPs exhibited better photostability and photothermal conversion efficiency. By tracking tumor-associated vessels and real-time tumor imaging, CS NPs could open/stop vascular targeting therapy by laser on/off. The combination of vessel disruption and imaging-guided photothermal therapy/photodynamic therapy provided a win–win strategy for oral squamous cell carcinoma (OSCC).

Photochemical α-Aminonitrile Synthesis using Zn Phthalocyanines as Near Infrared Photocatalysts

While photochemical transformations with sunlight almost exclusively utilize the UV-Vis part of the solar spectrum, the majority of the photons emitted by the sun have frequencies in the near-infrared region. Phthalocyanines show high structural similarity to the naturally occurring light harvesting porphyrins, chlorins and mainly bacteriochlorins, and are also known for being efficient and affordable near-infrared light absorbers as well as triplet sensitizers for the production of singlet oxygen. Although having been neglected for a long time in synthetic organic chemistry due to their low solubility and high tendency towards aggregation, their unique photophysical properties and chemical robustness make phthalocyanines attractive photocatalysts for the application in near-infrared light-driven synthesis strategies. Herein, we report a cheap, simple and efficient photocatalytic protocol, which is easily scalable under continuous flow conditions. Various phthalocyanines were studied as near-infrared photosensitizers in oxidative cyanations of tertiary amines to generate α-aminonitriles, a synthetically versatile compound class.

Age and sex trends of Gardnerella vaginalis infection in patients with sexually transmitted infections in Korea

Background and Objectives: Gardnerella vaginalis and Candida albicans are the most common causative agents of bac- terial vaginosis, and infections with these pathogens lead to inflammation, endometritis, and pruritus. The aim of this retro- spective study was to determine the trends of G. vaginalis infections based on real-time PCR data according to age and sex in patients with sexually transmitted diseases. Materials and Methods: A total of 59,381 specimens isolated at a clinical laboratory from September 2018 to December 2020 were subjected to real-time PCR for the detection of G. vaginalis DNA. Sample types included catheter, pus, tissue, swab, and urine samples. Results: Among 59,381 samples, 20,718 (34.8%) were positive for G. vaginalis. Of the positive samples, 13,186 (63.7%) were from male patients and 7,532 (36.3%) were from female patients. Average patient age was 39.1 years (the average age of male and female patients was 38.34 and 40.43 years, respectively). Female patients younger than 19 years exhibited the highest incidence of G. vaginalis, at 71.57%, followed by 68.46% incidence in those aged 20-29 years; the lowest incidence was in women aged 40-49 years. Further, among specimen types, the highest number of G. vaginalis-positive specimens was obtained by the swab sampling method. Conclusion: From 2018 to 2020 in Korea, the number of tests conducted for bacterial vaginosis has increased, while the incidence of G. vaginalis infections appears to have decreased. the finding that female adolescents have a high tendency to carry the pathogen is important. and for effective surveillance of BV, sampling by cotton swabs and detection by multiplex PCR might be a good approach.