scholarly journals A Case Series of Laparoscopic Colorectal Resections with Natural Orifice Specimen Extraction and Systematic Literature Review

2021 ◽  
Vol 07 (03) ◽  
pp. e203-e208
Author(s):  
Nasir Zaheer Ahmad ◽  
Ray Swayamjoti ◽  
Karen Flashman ◽  
Syed Abul Hassan Naqvi ◽  
Jim Khan
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Meta Analysis ◽  
Operating Time ◽  
Case Series ◽  
Natural Orifice ◽  
Specimen Extraction ◽  
Short Term ◽  
Abdominal Incision ◽  
Natural Orifice Specimen Extraction

Abstract Background Minimal access surgery is associated with improved cosmetic and other short-term outcomes. Conventionally, an abdominal incision is made for specimen extraction. We assessed the feasibility of specimen extraction through one of the natural orifices and analyzed its impact on short-term outcomes. Methods A prospectively collected data were reviewed on consecutive patients who underwent natural orifice specimen extraction (NOSE) after laparoscopic colorectal surgery. The results were compared with a matched group who had transabdominal extraction (TAE) of the specimens. A systematic literature review was performed to compare our results. Results The combined median operating time for right and left colectomies was significantly higher in the NOSE group as compared with TAE group (260 vs. 150). There was no mortality in either group and no conversions to TAE in the NOSE group. No local metastasis or major iatrogenic injuries were reported at the time of retrieval. The results were comparable to those of a meta-analysis of randomized controlled trials. Conclusion The results of NOSE are comparable to those of TAEs. The absence of a minilaparotomy for specimen extraction may lead to a speedy recovery and better cosmesis.

Appraisal and Consideration of Natural Orifice Specimen Extraction Surgery in Colorectal Cancer

Nano LIFE ◽  
2019 ◽  
Vol 09 (04) ◽  
pp. 1930001
Author(s):  
Zheng-Wei Fu ◽  
Li-Xia Wang ◽  
Hai-Yan Ge
Keyword(s):  
Colorectal Cancer ◽  
Laparoscopic Colectomy ◽  
Endoscopic Surgery ◽  
Surgical Approach ◽  
Oncologic Outcomes ◽  
Natural Orifice ◽  
Specimen Extraction ◽  
Short Term ◽  
Natural Orifice Specimen Extraction ◽  
The Times

Although laparoscopic colectomy shows superior short-term outcomes and similar oncologic outcomes in comparison to conventional open colectomy, incision-related complications have weakened its advantages. The natural orifice transluminal endoscopic surgery (NOTES) has been considered as the most perfect surgical approach. However, monumental technical hurdles have precluded widely adoption of this technique. As a transient mode, the natural orifice specimen extraction surgery (NOSES) emerges as the times require. Although it is accepted by surgeons for the treatment of colorectal cancer, there are still many disputes that need to be solved.

scholarly journals Short-term effectiveness of COVID-19 vaccines in immunocompromised patients: a systematic literature review and meta-analysis

2022 ◽  
Author(s):  
Alexandre R.MD MarraMS ◽  
Takaaki Kobayashi ◽  
Hiroyuki Suzuki ◽  
Mohammed Alsuhaibani ◽  
Bruna Marques Tofaneto ◽  
...  
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Meta Analysis ◽  
Immunocompromised Patients ◽  
Short Term

scholarly journals The short-term effectiveness of coronavirus disease 2019 (COVID-19) vaccines among healthcare workers: a systematic literature review and meta-analysis

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Alexandre R. Marra ◽  
Takaaki Kobayashi ◽  
Hiroyuki Suzuki ◽  
Mohammed Alsuhaibani ◽  
Bruna Marques Tofaneto ◽  
...  
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Healthcare Workers ◽  
Meta Analysis ◽  
Diagnostic Odds Ratio ◽  
Vaccine Effectiveness ◽  
Cochrane Central Register ◽  
Short Term ◽  
Central Register ◽  
Stratified Analysis

Abstract Objective: Healthcare workers (HCWs) are at risk of COVID-19 due to high levels of SARS-CoV-2 exposure. Thus, effective vaccines are needed. We performed a systematic literature review and meta-analysis on COVID-19 short-term vaccine effectiveness among HCWs. Methods: We searched PubMed, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science from December 2019 to June 11, 2021, for studies evaluating vaccine effectiveness against symptomatic COVID-19 among HCWs. To meta-analyze the extracted data, we calculated the pooled diagnostic odds ratio (DOR) for COVID-19 between vaccinated and unvaccinated HCWs. Vaccine effectiveness was estimated as 100% × (1 − DOR). We also performed a stratified analysis for vaccine effectiveness by vaccination status: 1 dose and 2 doses of the vaccine. Results: We included 13 studies, including 173,742 HCWs evaluated for vaccine effectiveness in the meta-analysis. The vast majority (99.9%) of HCWs were vaccinated with the Pfizer/BioNTech COVID-19 mRNA vaccine. The pooled DOR for symptomatic COVID-19 among vaccinated HCWs was 0.072 (95% confidence interval [CI], 0.028–0.184) with an estimated vaccine effectiveness of 92.8% (95% CI, 81.6%–97.2%). In stratified analyses, the estimated vaccine effectiveness against symptomatic COVID-19 among HCWs who had received 1 dose of vaccine was 82.1% (95% CI, 46.1%–94.1%) and the vaccine effectiveness among HCWs who had received 2 doses was 93.5% (95% CI, 82.5%–97.6%). Conclusions: The COVID-19 mRNA vaccines are highly effective against symptomatic COVID-19, even with 1 dose. More observational studies are needed to evaluate the vaccine effectiveness of other COVID-19 vaccines, COVID-19 breakthrough after vaccination, and vaccine efficacy against new variants.

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