scholarly journals First clinical experiences with a novel endoscopic over-the-scope clip system

2017 ◽  
Vol 05 (03) ◽  
pp. E151-E156 ◽  
Author(s):  
Marco Dinelli ◽  
Barbara Omazzi ◽  
Paolo Andreozzi ◽  
Nicola Zucchini ◽  
Alessandro Redaelli ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Clinical Success ◽  
Endocrine Tumor ◽  
Intestinal Wall ◽  
R0 Resection ◽  
The Novel ◽  
Clinical Experiences ◽  
Endoscopic Full Thickness Resection ◽  
Over The Scope Clip ◽  
Otsc System

AbstractWe describe our experience with a new over-the-scope clip (OTSC) system (Padlock Clip™) in the treatment of 14 patients. Eight of the 14 patients were treated for closure of gastrointestinal fistulas (n = 4), iatrogenic gastrointestinal perforations (n = 2), or hemostasis of post-polypectomy bleeding (n = 2). The site of clipping was the lower gastrointestinal tract in five patients and the upper gastrointestinal tract in three patients. The clip was successfully delivered in seven out of the eight patients and clinical success was achieved in all patients. Endoscopic full thickness resection (EFTR) was performed to treat six patients: four with recurrent adenoma (n = 4), one with ulcerated nodules at ileorectal anastomosis, and one with a neuro-endocrine tumor of the rectum. A complete intestinal wall resection was achieved in three of the six patients (50 %) and an R0 resection in five of the six patients (83.3 %). No complications related to the procedure and no recurrence at endoscopic follow-up were observed in any patient. The novel Padlock Clip seems to be an effective and safe tool to treat gastrointestinal fistulas, perforations or post-polypectomy bleeding, and to perform EFTR.

scholarly journals Clinical outcomes of over-the-scope-clip system for the treatment of acute upper non-variceal gastrointestinal bleeding: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Chunyu Zhong ◽  
Shali Tan ◽  
Yutang Ren ◽  
MuHan Lü ◽  
Yan Peng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gastrointestinal Bleeding ◽  
Clinical Success ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Gi Bleeding ◽  
Search Terms ◽  
Over The Scope Clip ◽  
Otsc System ◽  
Upper Gastrointestinal

Abstract BackgroundConventional endoscopic treatments can’t control bleeding in as many as 20% of patients with non-variceal gastrointestinal (GI) bleeding. Recent studies have shown that over-the-scope-clip (OTSC) system allowed for effective hemostasis for refractory GI bleeding lesions. So we aimed to conduct a systematic review to evaluate the effectiveness and safety of the OTSC system for management of acute non-variceal upper GI bleeding.MethodA comprehensive literature search was conducted on PubMed, EMBASE, and Cochrane Library covering the period from January 2007 to May 2019. The search terms included “gastrointestinal bleeding” AND “OTSC OR over the scope clip”. The literature was selected independently by two reviewers according to the inclusion and exclusion criteria. The statistical analysis was carried out using Comprehensive Meta-Analysis software version 3.0.ResultsA total of 16 studies including 769 patients with 778 GI bleeding lesions were identified. Pooled technical success was achieved in 761 lesions [95.7%; 95% confidence interval (CI), 93.5%-97.2%], and the pooled clinical success was achieved in 666 lesions (84.2%; 95% CI, 77.4%-89.2%). The incidence of re-bleeding was reported in 81 patients and the post-procedure mortality was 10.9% (n=84). Only 2 (0.3%) patients occurred complications after OTSC system procedure.ConclusionsOur study demonstrated that the OTSC system was a technically feasible modality and highly efficacious in achieving hemostasis in acute non-variceal upper gastrointestinal bleeding.

scholarly journals Resection of a Nonampullary Adenoma with the New Gastroduodenal Full-Thickness Resection Device

2020 ◽  
Vol 11 (03) ◽  
pp. 242-244
Author(s):  
Maximilian Gericke ◽  
Matthias Mende ◽  
Dirk Hartmann ◽  
Siegbert Faiss
Keyword(s):  
Gastrointestinal Tract ◽  
Surgical Resection ◽  
Endoscopic Resection ◽  
Significant Risk ◽  
R0 Resection ◽  
High Morbidity ◽  
Full Thickness ◽  
Endoscopic Full Thickness Resection ◽  
Upper Gastrointestinal ◽  
Subepithelial Tumors

Abstract Introduction Surgical resection of adenomas or subepithelial tumors in the duodenum has a high morbidity compared with endoscopic resection which also has a significant risk of complication. Endoscopic full-thickness resection has shown its feasibility and safety in the colorectum and in the upper gastrointestinal tract. Patient and Methods We present the new gastroduodenal full-thickness resection device (FTRD) for full-thickness resection in a patient with a recurrent nonlifting adenoma in the nonampullary duodenum. Results The procedure was successful with R0 resection without major complications. A control gastroscopy showed no recurrence of the adenoma. Conclusion The gastroduodenal FTRD seems to be a promising new technique for resecting nonlifting adenomas in the nonampullary duodenum.

scholarly journals Endoscopic Treatment of a Gastrocutaneous Fistula Using the Over-The-Scope-Clip System: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Georgios Kouklakis ◽  
Petros Zezos ◽  
Nikolaos Liratzopoulos ◽  
Anthia Gatopoulou ◽  
Anastasia Oikonomou ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Mechanical Compression ◽  
Fistula Closure ◽  
Endoscopic Closure ◽  
System A ◽  
Perforated Gastric Ulcer ◽  
Over The Scope Clip ◽  
Otsc System ◽  
Gastrocutaneous Fistula ◽  
Endoscopic Application

The over-the-scope-clip (OTSC; Ovesco Endoscopy GmbH, Tuebingen, Germany) system is a newly designed method for the mechanical compression of large areas in the gastrointestinal tract. So far, indications for OTSC application are hemostasis of primary or postinterventional bleeding, closure of iatrogenic full-thickness or covered perforations. Recently closure of gastrointestinal tract fistulas using this device has been described. A 44-year-old man developed a gastrocutaneous fistula after surgical treatment for a perforated gastric ulcer. We describe the successful endoscopic closure of the fistula using the OTSC system. The patient's clinical followup was uneventful. Fistula closure was successfully implemented as it was documented by imaging and endoscopic examinations performed on the 2nd day and 6th week after the application of the clip. Endoscopic application of the OTSC device was safe and effective for the treatment of a gastrocutaneous fistula.

scholarly journals Clinical outcomes of over-the-scope-clip system for the treatment of acute upper non-variceal gastrointestinal bleeding: a systematic review and meta-analysis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Chunyu Zhong ◽  
Shali Tan ◽  
Yutang Ren ◽  
Muhan Lü ◽  
Yan Peng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gastrointestinal Bleeding ◽  
Clinical Success ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Gi Bleeding ◽  
Exclusion Criteria ◽  
Over The Scope Clip ◽  
Otsc System ◽  
Upper Gastrointestinal

Abstract Background Conventional endoscopic treatments can’t control bleeding in as many as 20% of patients with non-variceal gastrointestinal (GI) bleeding. Recent studies have shown that over-the-scope-clip (OTSC) system allowed for effective hemostasis for refractory GI bleeding lesions. So we aimed to conduct a systematic review to evaluate the effectiveness and safety of the OTSC system for management of acute non-variceal upper GI bleeding. Method A comprehensive literature search was conducted on PubMed, EMBASE, and Cochrane Library covering the period from January 2007 to May 2019. The literature was selected independently by two reviewers according to the inclusion and exclusion criteria. The statistical analysis was carried out using Comprehensive Meta-Analysis software version 3.0. Results A total of 16 studies including 769 patients with 778 GI bleeding lesions were identified. Pooled technical success was achieved in 761 lesions [95.7%; 95% confidence interval (CI), 93.5–97.2%], and the pooled clinical success was achieved in 666 lesions (84.2, 95% CI, 77.4–89.2%). The incidence of re-bleeding was reported in 81 patients and the post-procedure mortality was 10.9% (n = 84). Only 2 (0.3%) patients occurred complications after OTSC system procedure. Conclusions Our study demonstrated that the OTSC system was a technically feasible modality and highly efficacious in achieving hemostasis in acute non-variceal upper gastrointestinal bleeding.

scholarly journals S2527 Endoscopic Full-Thickness Resection of Gastric Subepithelial Lesions Using a Novel Over-The-Scope-Clip (OTSC) System

2021 ◽  
Vol 116 (1) ◽  
pp. S1066-S1067
Author(s):  
Anastasia Chahine ◽  
Samuel Ji ◽  
Peter H. Nguyen ◽  
Sagar Shah ◽  
Jennifer Kolb ◽  
...  
Keyword(s):  
Full Thickness ◽  
Endoscopic Full Thickness Resection ◽  
Over The Scope Clip ◽  
Otsc System ◽  
Subepithelial Lesions

scholarly journals Clinical outcomes of over-the-scope-clip system for the treatment of acute upper non-variceal gastrointestinal bleeding: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Chunyu Zhong ◽  
Shali Tan ◽  
Yutang Ren ◽  
MuHan Lü ◽  
Yan Peng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gastrointestinal Bleeding ◽  
Clinical Success ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Gi Bleeding ◽  
Exclusion Criteria ◽  
Over The Scope Clip ◽  
Otsc System ◽  
Upper Gastrointestinal

Abstract Background: Conventional endoscopic treatments can’t control bleeding in as many as 20% of patients with non-variceal gastrointestinal (GI) bleeding. Recent studies have shown that over-the-scope-clip (OTSC) system allowed for effective hemostasis for refractory GI bleeding lesions. So we aimed to conduct a systematic review to evaluate the effectiveness and safety of the OTSC system for management of acute non-variceal upper GI bleeding. Method: A comprehensive literature search was conducted on PubMed, EMBASE, and Cochrane Library covering the period from January 2007 to May 2019. The literature was selected independently by two reviewers according to the inclusion and exclusion criteria. The statistical analysis was carried out using Comprehensive Meta-Analysis software version 3.0. Results: A total of 16 studies including 769 patients with 778 GI bleeding lesions were identified. Pooled technical success was achieved in 761 lesions [95.7%; 95% confidence interval (CI), 93.5%-97.2%], and the pooled clinical success was achieved in 666 lesions (84.2%; 95% CI, 77.4%-89.2%). The incidence of re-bleeding was reported in 81 patients and the post-procedure mortality was 10.9% (n = 84). Only 2 (0.3%) patients occurred complications after OTSC system procedure. Conclusions: Our study demonstrated that the OTSC system was a technically feasible modality and highly efficacious in achieving hemostasis in acute non-variceal upper gastrointestinal bleeding.

scholarly journals Over-the-scope clip-assisted endoscopic full-thickness resection has potential to treat complex nonampullary duodenal lesions: a single-center case series

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yongqiu Wei ◽  
Qiaozhi Zhou ◽  
Ming Ji ◽  
Shutian Zhang ◽  
Peng Li
Keyword(s):  
Endoscopic Resection ◽  
Case Series ◽  
Muscularis Propria ◽  
Complete Resection ◽  
R0 Resection ◽  
Full Thickness ◽  
Retrospective Case ◽  
Duodenal Lesions ◽  
Endoscopic Full Thickness Resection ◽  
Over The Scope Clip

Abstract Background and aims The duodenum is considered a challenging area for the endoscopic resection of lesions. This study aimed to evaluate the efficacy and safety of over-the-scope clip (OTSC)-assisted endoscopic full-thickness resection (EFTR) for complex nonampullary duodenal lesions unsuitable for conventional resection techniques. Methods and patients We conducted a retrospective case review of 13 consecutive patients with complex nonampullary duodenal tumors that were unsuitable for conventional resection techniques; these patients underwent EFTR assisted with OTSC at Beijing Friendship Hospital, Capital Medical University from September 2015 to September 2020. The OTSC device was placed, and tumors were resected after the lesions were identified. Data were abstracted for demographics, lesion features, histopathologic diagnoses, technical success rates, complete resection (R0 resection) rates, and complications. Results Thirteen patients with duodenal lesions (6 adenomas and 7 submucosal tumors with nonlifting signs, incomplete lifting signs, difficult locations, failed ESD/EMR attempts or suspected origin in the muscularis propria) subjected to EFTR were included. The sizes of all the lesions evaluated by endoscopy were smaller than 20 mm, and most of them (84.6%, 11/13) were smaller than 12 mm. All 13 applications of the clips, endoscopic resection and full-thickness resection were successful (13/13, 100%). Complete resection was achieved in 12 patients (12/13, 92.3%). There were no immediate or delayed complications, including bleeding, infection and perforation. Conclusions OTSC -assisted EFTR appears to be effective and safe for complex nonampullary duodenal lesions smaller than 20 mm (particularly those ≤ 10–12 mm) that are unsuitable for conventional resection techniques.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

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