Tissue engineering of heart valves: Monocyte chemotactic activity in decellularized heart valve tissue

2004 ◽  
Vol 52 (S 1) ◽  
Author(s):  
E Rieder ◽  
MT Kasimir ◽  
G Seebacher ◽  
E Wolner ◽  
P Simon ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Heart Valve ◽  
Heart Valves ◽  
Chemotactic Activity ◽  
Valve Tissue ◽  
Heart Valve Tissue

Specimen Dynamics and Subsequent Implications in Heart Valve Tissue Engineering Studies

2011 ◽  
Author(s):  
M. Salinas ◽  
R. Lange ◽  
S. Ramaswamy
Keyword(s):  
Tissue Engineering ◽  
Heart Valve ◽  
Heart Valves ◽  
Fluid Dynamic ◽  
Critical Role ◽  
Tissue Growth ◽  
Valve Tissue ◽  
Heart Valve Tissue ◽  
Heart Valve Tissue Engineering ◽  
Stress States

In heart valve tissue engineering, appropriate mechanical preconditioning may provide the necessary stimuli to promote proper tissue formation [1–3]. Previous efforts have focused on a mechanistic heart valve (MHV) bioreactor that can mimic the innate mechanical stress states of flexure, flow and stretch in any combination thereof [1]. A fundamental component pertaining to heart valves is its dynamic behavior. Specific fluid-induced shears stress patterns may play a critical role in up-regulating ECM secretion by progenitor cell sources such as bone marrow derived stem cells [2] and increasing the possibility of cell differentiation towards a heart valve phenotype. Here, we take a computational predictive modeling approach to identify the specific fluid induced shear stress distributions that are altered as a result of valve-like movement and its resulting implications for tissue growth. Previous results have demonstrated the analogous deformation characteristics of heart valves in a rectangular geometry [2]. We conducted computational fluid dynamic (CFD) simulations of a bioreactor that houses these rectangular-shaped specimens (Fig.1).

Translating Autologous Heart Valve Tissue Engineering from Bench to Bed

2009 ◽  
Vol 15 (3) ◽  
pp. 307-317 ◽  
Author(s):  
Jesper Hjortnaes ◽  
Carlijn V.C. Bouten ◽  
Lex A. Van Herwerden ◽  
Paul F. Gründeman ◽  
Jolanda Kluin
Keyword(s):  
Tissue Engineering ◽  
Heart Valve ◽  
Valve Tissue ◽  
Heart Valve Tissue ◽  
Heart Valve Tissue Engineering

scholarly journals In vivo cellularization of a cross-linked matrix by intraperitoneal implantation: a new tool in heart valve tissue engineering

2007 ◽  
Vol 28 (11) ◽  
pp. 1389-1396 ◽  
Author(s):  
G. De Visscher ◽  
I. Vranken ◽  
A. Lebacq ◽  
C. Van Kerrebroeck ◽  
J. Ganame ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Heart Valve ◽  
Valve Tissue ◽  
Heart Valve Tissue ◽  
Heart Valve Tissue Engineering
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