[18F]Repaglinide: A Novel Radioligand for estimation of pancreatic islet-cell mass in vivo with Positron Emission Tomography (PET)

2004 ◽  
Vol 112 (S 1) ◽  
Author(s):  
S Schneider ◽  
B Wängler ◽  
O Thews ◽  
E Schirrmacher ◽  
S Comagic ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Cell Mass ◽  
Emission Tomography ◽  
Pancreatic Islet Cell ◽  
Positron Emission

Improved Staging of Patients With Carcinoid and Islet Cell Tumors With18F-Dihydroxy-Phenyl-Alanine and11C-5-Hydroxy-Tryptophan Positron Emission Tomography

2008 ◽  
Vol 26 (9) ◽  
pp. 1489-1495 ◽  
Author(s):  
Klaas P. Koopmans ◽  
Oliver C. Neels ◽  
Ido P. Kema ◽  
Philip H. Elsinga ◽  
Wim J. Sluiter ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Emission Tomography ◽  
Islet Cell Tumors ◽  
Pancreatic Islet Cell ◽  
Tumor Patients ◽  
Positron Emission ◽  
Pet Ct

PurposeTo evaluate and compare diagnostic sensitivity of positron emission tomography (PET) scanning in carcinoid and islet cell tumor patients with a serotonin and a catecholamine precursor as tracers.Patients and MethodsCarcinoid (n = 24) or pancreatic islet cell tumor (n = 23) patients with at least one lesion on conventional imaging including somatostatin receptor scintigraphy (SRS) and computed tomography (CT) scan underwent11C-5-hydroxytryptophan (11C-5-HTP) PET and 6-[F-18]fluoro-L-dihydroxy-phenylalanin (18F-DOPA) PET. PET findings were compared with a composite reference standard derived from all available imaging along with clinical and cytologic/histologic information.ResultsIn carcinoid tumor patients, per-patient analysis showed sensitivities for11C-5-HTP PET,18F-DOPA PET, SRS, and CT of 100%, 96%, 86%, 96%, respectively, and in islet cell tumors of 100%, 89%, 78%, 87%, respectively. In carcinoid patients, per-lesion analysis revealed sensitivities for11C-5-HTP PET,11C-5-HTP PET/CT,18F-DOPA PET,18F-DOPA PET/CT, SRS, SRS/CT, and CT alone of, respectively, 78%, 89%, 87%, 98%, 49%, 73%, and 63% and in islet cell tumors of 67%, 96%, 41%, 80%, 46%, 77%, and 68%, respectively. In all carcinoid patients18F-DOPA PET and11C-5-HTP PET detected more lesions than SRS (P < .001).11C-5-HTP PET was superior to18F-DOPA PET in islet cell tumors (P < .0001). In all cases, CT improved the sensitivity of the nuclear scans.Conclusion18F-DOPA PET/CT is the optimal imaging modality for staging in carcinoid patients and11C-5-HTP PET/CT in islet cell tumor patients.

Quantitative micro positron emission tomography (PET) imaging for the in vivo determination of pancreatic islet graft survival

2006 ◽  
Vol 12 (12) ◽  
pp. 1423-1428 ◽  
Author(s):  
Su-Jin Kim ◽  
Doris J Doudet ◽  
Andrei R Studenov ◽  
Cuilan Nian ◽  
Thomas J Ruth ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Graft Survival ◽  
Pancreatic Islet ◽  
Pet Imaging ◽  
Emission Tomography ◽  
Islet Graft ◽  
Positron Emission

scholarly journals Development of a blood sample detector for multi-tracer positron emission tomography using gamma spectroscopy

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Carlos Velasco ◽  
Adriana Mota-Cobián ◽  
Jesús Mateo ◽  
Samuel España
Keyword(s):  
Positron Emission Tomography ◽  
Blood Sample ◽  
Pet Imaging ◽  
Spectroscopic Analysis ◽  
Gamma Spectroscopy ◽  
Emission Tomography ◽  
Blood Samples ◽  
Positron Emission

Abstract Background Multi-tracer positron emission tomography (PET) imaging can be accomplished by applying multi-tracer compartment modeling. Recently, a method has been proposed in which the arterial input functions (AIFs) of the multi-tracer PET scan are explicitly derived. For that purpose, a gamma spectroscopic analysis is performed on blood samples manually withdrawn from the patient when at least one of the co-injected tracers is based on a non-pure positron emitter. Alternatively, these blood samples required for the spectroscopic analysis may be obtained and analyzed on site by an automated detection device, thus minimizing analysis time and radiation exposure of the operating personnel. In this work, a new automated blood sample detector based on silicon photomultipliers (SiPMs) for single- and multi-tracer PET imaging is presented, characterized, and tested in vitro and in vivo. Results The detector presented in this work stores and analyzes on-the-fly single and coincidence detected events. A sensitivity of 22.6 cps/(kBq/mL) and 1.7 cps/(kBq/mL) was obtained for single and coincidence events respectively. An energy resolution of 35% full-width-half-maximum (FWHM) at 511 keV and a minimum detectable activity of 0.30 ± 0.08 kBq/mL in single mode were obtained. The in vivo AIFs obtained with the detector show an excellent Pearson’s correlation (r = 0.996, p < 0.0001) with the ones obtained from well counter analysis of discrete blood samples. Moreover, in vitro experiments demonstrate the capability of the detector to apply the gamma spectroscopic analysis on a mixture of 68Ga and 18F and separate the individual signal emitted from each one. Conclusions Characterization and in vivo evaluation under realistic experimental conditions showed that the detector proposed in this work offers excellent sensibility and stability. The device also showed to successfully separate individual signals emitted from a mixture of radioisotopes. Therefore, the blood sample detector presented in this study allows fully automatic AIFs measurements during single- and multi-tracer PET studies.

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