Results of Multimodal Treatment of Two Patients with Thoracic Primitive Neuroectodermal Tumor. Is Surgery Really Helpful for Survival?

<p>Extraskeletal Ewing’s sarcoma (EES) commonly arises in the soft tissues of trunk or extremities. EES is rare in the head and neck region; most having been documented in nasal cavity, paranasal sinuses and neck. Head and neck PNETs have an intermediate prognosis. We report the case of a 12 year old boy who presented with primitive neuroectodermal tumor of the thyroid and was treated with multimodal treatment including surgery, chemotherapy and radiotherapy. The patient is alive and fit with a functional larynx. Major drug regimens use vincristine, doxorubicin, ifosfamide or cyclophosphamide, dactinomycin and/or etoposide. Complete surgical excision is undertaken whenever possible to improve long-term survival. However, the relative radiosensitivity of tumors of the Ewing family, suggest multimodal treatment including adjuvant radiotherapy in case of positive margins or poor response to chemotherapy rather than resection with 2-3 cm margins, which would imply laryngeal sacrifice for thyroid tumors.</p>

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Primitive neuroectodermal tumor of the uterus: Excellent clinical response following a multimodal treatment approach

Gynecologic Oncology Reports ◽

10.1016/j.gore.2020.100550 ◽

2020 ◽

Vol 32 ◽

pp. 100550

Author(s):

Adam Khorasanchi ◽

Elizabeth Kertowidjojo ◽

Sara Kim ◽

William Burke ◽

Andrzej Kudelka

Keyword(s):

Clinical Response ◽

Multimodal Treatment ◽

Primitive Neuroectodermal Tumor ◽

Treatment Approach ◽

Neuroectodermal Tumor ◽

Multimodal Treatment Approach

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Peripheral Primitive Neuroectodermal Tumor: Challenge for Multimodal Treatment

World Journal of Surgery ◽

10.1007/s00268-001-0142-0 ◽

2001 ◽

Vol 25 (11) ◽

pp. 1367-1372 ◽

Cited By ~ 24

Author(s):

Thomas Zimmermann ◽

Renate Blütters-Sawatzki, M.D. ◽

Klaus Flechsenhar, M.D. ◽

Winfried M. Padberg, M.D.

Keyword(s):

Multimodal Treatment ◽

Primitive Neuroectodermal Tumor ◽

Neuroectodermal Tumor ◽

Peripheral Primitive Neuroectodermal Tumor ◽

Tumor Challenge

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Membranous alterations in the cytoplasm and nucleus in a primitive neuroectodermal tumor of the brain

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100084016 ◽

1978 ◽

Vol 36 (2) ◽

pp. 628-629

Author(s):

C. N. Sun ◽

C. Araoz ◽

H. J. White

Keyword(s):

Nuclear Envelope ◽

Tumor Cells ◽

Osmium Tetroxide ◽

Primitive Neuroectodermal Tumor ◽

Uranyl Acetate ◽

Neuroectodermal Tumor ◽

Annulate Lamellae ◽

Lead Citrate ◽

Thin Sections ◽

The Brain

The ultrastructure of a cerebral primitive neuroectodermal tumor has been reported previously. In the present case, we will present some unusual previously unreported membranous structures and alterations in the cytoplasm and nucleus of the tumor cells.Specimens were cut into small pieces about 1 mm3 and immediately fixed in 4% glutaraldehyde in phosphate buffer for two hours, then post-fixed in 1% buffered osmium tetroxide for one hour. After dehydration, tissues were embedded in Epon 812. Thin sections were stained with uranyl acetate and lead citrate.In the cytoplasm of the tumor cells, we found paired cisternae (Fig. 1) and annulate lamellae (Fig. 2) noting that the annulate lamellae were sometimes associated with the outer nuclear envelope (Fig. 3). These membranous structures have been reported in other tumor cells. In our case, mitochondrial to nuclear envelope fusions were often noted (Fig. 4). Although this phenomenon was reported in an oncocytoma, their frequency in the present study is quite striking.

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