The Influence of Alprazolam on the Monoaminergic Neurotransmitter Systems in Dysthymic Patients. Relationship to Clinical Response

1998 ◽  
Vol 31 (04) ◽  
pp. 131-136 ◽  
Author(s):  
G. Santagostino ◽  
Maria Cucchi ◽  
P. Frattini ◽  
F. Zerbi ◽  
E. Di Paolo ◽  
...  
Keyword(s):  
Clinical Response ◽  
Neurotransmitter Systems ◽  
Monoaminergic Neurotransmitter

Pathogenesis of Depression: Clinical Studies

2013 ◽  
pp. 438-441
Author(s):  
Maura A. Furey ◽  
Daniel C. Mathews ◽  
Carlos A. Zarate
Keyword(s):  
Treatment Outcome ◽  
Clinical Research ◽  
Clinical Response ◽  
Mood Disorders ◽  
Clinical Studies ◽  
Neurotransmitter Systems ◽  
Antidepressant Effects ◽  
Underlying Pathophysiology ◽  
Cholinergic Neurotransmitter ◽  
Clinical And Translational Research

Historically, research focused on themonoaminergicsystemshas contributed to our understanding of theunderlying pathophysiology of affective disorders.Recent directions in clinical and translational research have concentrated on discovering alternative therapeutic targets with the hopes of producing more efficacious and faster-acting antidepressant agents.This chapter offers an overview of recent clinical research targeting the glutamatergic and cholinergic neurotransmitter systems, with particular interest in novel agents that have produced rapid antidepressant effects. Insights into the underlying pathophysiology of mood disorders resulting from this work are reviewed. In addition, the rapidity of clinical response offers the unique opportunity to studybiological markers more efficiently , and to utilize biomarkers to predict treatment outcome. The findings from such studies also are summarized.

Clinical Response to Questions Regarding Outcomes and Therapy Efficacy

2010 ◽  
Vol 20 (3) ◽  
pp. 76-83 ◽  
Author(s):  
Joseph Donaher ◽  
Tom Gurrister ◽  
Irving Wollman ◽  
Tim Mackesey ◽  
Michelle L. Burnett
Keyword(s):  
Risk Factors ◽  
Clinical Response ◽  
Speech Language Pathologists ◽  
Specific Therapy ◽  
Therapy Efficacy ◽  
Therapy Program ◽  
Adults Who Stutter ◽  
Cure Rates

Parents of children who stutter and adults who stutter frequently ask speech-language pathologists to predict whether or not therapy will work. Even though research has explored risk-factors related to persistent stuttering, there remains no way to determine how an individual will react to a specific therapy program. This paper presents various clinicians’answers to the question, “What do you tell parents or adults who stutter when they ask about cure rates, outcomes, and therapy efficacy?”

Primary chemoprevention of familial adenomalous polyposis: Stratification of clinical response to sulindac by mucosal prostanoid levels

2001 ◽  
Vol 120 (5) ◽  
pp. A253-A253
Author(s):  
V YANG ◽  
R CASERO ◽  
D GEIMAN ◽  
W HUBBARD ◽  
L HYLIND ◽  
...  
Keyword(s):  
Clinical Response
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