Transient Reversal of Thrombocytopenia in Idiopathic Thrombocytopenic Purpura by High-Dose Intravenous Gamma Globulin

1982 ◽  
Vol 306 (21) ◽  
pp. 1254-1258 ◽  
Author(s):  
Jorg Fehr ◽  
Victor Hofmann ◽  
Urs Rappeler
Keyword(s):  
Idiopathic Thrombocytopenic Purpura ◽  
Gamma Globulin ◽  
High Dose ◽  
Thrombocytopenic Purpura ◽  
Intravenous Gamma Globulin

scholarly journals A Case of Epistaxis as the First Sign of Acute Idiopathic Thrombocytopenic Purpura

2021 ◽  
Vol 2021 ◽  
pp. 1-4 ◽  
Author(s):  
Shori Tajima ◽  
Fumihiko Matsumoto ◽  
Takashi Anzai ◽  
Satoshi Hara ◽  
Yo Suzuki ◽  
...  
Keyword(s):  
Platelet Count ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Blood Count ◽  
Gamma Globulin ◽  
Full Blood Count ◽  
Thrombocytopenic Purpura ◽  
Platelet Level ◽  
Intravenous Gamma Globulin ◽  
Nasal Bleeding ◽  
Nose And Throat

Idiopathic thrombocytopenic purpura (ITP) is an acquired thrombocytopenia caused by the action of autoantibodies against platelet antigens. It is traditionally defined by a platelet count of less than 10 × 104/μL. Most patients with ITP are asymptomatic; however, symptoms have been confirmed in some cases. Conversely, it is very rare to find epistaxis as the first sign of ITP. We report the case of an 84-year-old man who came to the ear, nose, and throat department with severe and repeated epistaxis. We decided to keep him hospitalized as it was very difficult to stop the nasal bleeding. A full blood count showed a platelet level of only 1000/μL. Hematologic results confirmed the diagnosis of ITP. The patient underwent treatment with intravenous gamma-globulin, platelet transfusions, and romiplostim with a favorable response.

Prolongation of Platelet Survival in Idiopathic Thrombocytopenic Purpura by High-Dose Intravenous Gamma Globulin

1984 ◽  
Vol 51 (01) ◽  
pp. 065-066 ◽  
Author(s):  
T Uchida ◽  
T Yui ◽  
H Umezu ◽  
S Kariyone
Keyword(s):  
Bone Marrow ◽  
Gamma Globulin ◽  
Reticuloendothelial System ◽  
High Dose ◽  
Platelet Destruction ◽  
Thrombocytopenic Purpura ◽  
Platelet Survival ◽  
Before And After ◽  
Intravenous Gamma Globulin ◽  
Platelet Release

SummaryThe mechanism of the increase of platelet counts after the intravenous injection of high dose gammaglobulin was evaluated by measuring platelet survival before and after the injection. The platelet survival after treatment prolonged more significantly than that before treatment. There was no evidence of platelet release from bone marrow to peripheral blood. These findings might suggest the inhibition of platelet destruction by transient blockade of reticuloendothelial system.

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