The determination of enantiomeric purity and absolute configuration by vibrational circular dichroism spectroscopy

1998 ◽  
Author(s):  
Laurence A. Nafie ◽  
Fujin Long ◽  
Teresa B. Freedman ◽  
Henry Buijs ◽  
Allan Rilling ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Absolute Configuration ◽  
Circular Dichroism Spectroscopy ◽  
Enantiomeric Purity ◽  
Vibrational Circular Dichroism ◽  
Circular Dichroïsm

scholarly journals VCD Determination of the Absolute Configuration of Stypotriol

2009 ◽  
Vol 4 (8) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Marcelo A. Muñoz ◽  
Carlos Areche ◽  
Aurelio San-Martín ◽  
Juana Rovirosa ◽  
Pedro Joseph-Nathan
Keyword(s):  
Circular Dichroism ◽  
Natural Product ◽  
Absolute Configuration ◽  
Circular Dichroism Spectroscopy ◽  
Vibrational Circular Dichroism ◽  
Stypopodium Zonale ◽  
The Absolute ◽  
Circular Dichroïsm

The absolute configuration of the pentacyclic ichthyotoxin stypotriol, a constituent of Stypopodium zonale, was deduced to be 3S,5R,8R,9R,10S,13S,14S-(-)-1 by vibrational circular dichroism spectroscopy of the derived triacetate 2 in comparison to DFT B3LYP/DGDZVP calculations. Compound 2, C33H46O7 having 300 electrons, is the largest natural product successfully studied by VCD to date.

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