Expression of a retinol dehydrogenase (hRoDH-4), a member of the retinol/steroid dehydrogenase family implicated in retinoic acid biosynthesis, in normal and neoplastic endometria

2002 ◽  
Vol 186 (4) ◽  
pp. 675-683 ◽  
Author(s):  
Joanna M. Cain ◽  
Richard Zaino ◽  
Debra Shearer ◽  
R.Alan Bennett ◽  
George Olt ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Acid Biosynthesis ◽  
Retinol Dehydrogenase ◽  
Retinoic Acid Biosynthesis ◽  
Steroid Dehydrogenase

Expression of genes involved in retinoic acid biosynthesis in human gastric cancer

2013 ◽  
Vol 47 (2) ◽  
pp. 280-292 ◽  
Author(s):  
E. S. Kropotova ◽  
O. L. Zinov’eva ◽  
A. F. Zyryanova ◽  
E. L. Choinzonov ◽  
S. G. Afanas’ev ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Retinoic Acid ◽  
Human Gastric Cancer ◽  
Acid Biosynthesis ◽  
Expression Of Genes ◽  
Retinoic Acid Biosynthesis

scholarly journals Aldehyde Oxidase Contributes to all-trans-Retinoic Acid Biosynthesis in Human Liver

2020 ◽  
pp. DMD-AR-2020-000296
Author(s):  
Guo Zhong ◽  
Chris J. Seaman ◽  
Erickson M. Paragas ◽  
Huanqing Xi ◽  
Karla-Luise Herpoldt ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Human Liver ◽  
Aldehyde Oxidase ◽  
Acid Biosynthesis ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Retinoic Acid Biosynthesis

scholarly journals Isomer‐specific retinoic acid biosynthesis in HeLa cells expressing recombinant class I aldehyde dehydrogenases

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Pangala V Bhat ◽  
Helen Brodeur ◽  
Samuel Chagnon ◽  
Maxime Parisotto ◽  
Sylvie Mader
Keyword(s):  
Retinoic Acid ◽  
Hela Cells ◽  
Class I ◽  
Acid Biosynthesis ◽  
Aldehyde Dehydrogenases ◽  
Retinoic Acid Biosynthesis

scholarly journals Generation of Retinaldehyde for Retinoic Acid Biosynthesis

Biomolecules ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 5 ◽  
Author(s):  
Olga V. Belyaeva ◽  
Mark K. Adams ◽  
Kirill M. Popov ◽  
Natalia Y. Kedishvili
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Tissue Distribution ◽  
Acid Biosynthesis ◽  
Physiological Processes ◽  
Current State ◽  
Trans Retinoic Acid ◽  
Irreversible Oxidation ◽  
All Trans Retinoic Acid ◽  
Retinoic Acid Biosynthesis

The concentration of all-trans-retinoic acid, the bioactive derivative of vitamin A, is critically important for the optimal performance of numerous physiological processes. Either too little or too much of retinoic acid in developing or adult tissues is equally harmful. All-trans-retinoic acid is produced by the irreversible oxidation of all-trans-retinaldehyde. Thus, the concentration of retinaldehyde as the immediate precursor of retinoic acid has to be tightly controlled. However, the enzymes that produce all-trans-retinaldehyde for retinoic acid biosynthesis and the mechanisms responsible for the control of retinaldehyde levels have not yet been fully defined. The goal of this review is to summarize the current state of knowledge regarding the identities of physiologically relevant retinol dehydrogenases, their enzymatic properties, and tissue distribution, and to discuss potential mechanisms for the regulation of the flux from retinol to retinaldehyde.

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