scholarly journals Delayed detection of motor pathway dysfunction after selective reduction of thoracic spinal cord blood flow in pigs

2002 ◽  
Vol 123 (3) ◽  
pp. 531-538 ◽  
Author(s):  
Jeroen Lips ◽  
Peter de Haan ◽  
Gerrit J. Bouma ◽  
Michael J. Jacobs ◽  
Cor J. Kalkman
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Selective Reduction ◽  
Spinal Cord Blood Flow ◽  
Thoracic Spinal Cord ◽  
Motor Pathway ◽  
Thoracic Spinal

Regional spinal cord blood flow in primates

1976 ◽  
Vol 45 (6) ◽  
pp. 647-659 ◽  
Author(s):  
Alan N. Sandler ◽  
Charles H. Tator
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Gray Matter ◽  
Mean Value ◽  
Spinal Cord Blood Flow ◽  
Thoracic Spinal Cord ◽  
Content Type ◽  
Arterial Blood ◽  
Thoracic Spinal

✓ Spinal cord blood flow (SCBF) was measured in the primate thoracic spinal cord using the 14C-antipyrine autoradiographic technique that allowed clear differentiation between white and gray matter blood flow. Individual SCBF values were obtained for 0.1-sq mm areas of the thoracic cord cross section. White matter blood flow was homogeneous throughout with a mean value of 10.3 ± 0.2 ml/100 gm/min. Graymatter flow was more variable with lower values in the dorsal horns and higher values in the central gray and anterior horns. Mean gray-matter flow was 57.6 ± 2.3 ml/100 gm/min. Arterial pO2 was 123 ± 2 torr, pCO2 was 40.2 ± 0.5 torr and pH was 7.327 ± 0.010. Mean arterial blood pressure was 113 ± 3 mm Hg and core temperature was 36.4° ± 0.1° C.

Cardiorespiratory and Spinal Cord Blood Flow Effects of Intrathecal Neostigmine Methylsulfate, Clonidine, and Their Combination in Sheep 

1995 ◽  
Vol 82 (2) ◽  
pp. 428-435 ◽  
Author(s):  
David D. Hood ◽  
James C. Eisenach ◽  
Chuanyao Tong ◽  
Ellen Tommasi ◽  
Tony L. Yaksh
Keyword(s):  
Spinal Cord ◽  
Clinical Trials ◽  
Blood Flow ◽  
Cord Blood ◽  
Intrathecal Injection ◽  
Central Venous ◽  
Spinal Cord Blood Flow ◽  
Arterial Blood ◽  
Thoracic Spinal ◽  
Flow Effects

Background Intrathecal neostigmine may produce analgesia by itself and may enhance analgesia from spinal clonidine. Before clinical trials, the spinal cord blood flow effects of these drugs alone and in combination should be examined in animals. Methods Conscious, nonpregnant ewes with indwelling vascular and thoracic spinal catheters received intrathecal injection of 0.2 or 2 mg neostigmine, 0.2 mg clonidine, or 2 mg neostigmine plus 0.2 mg clonidine. Mean systemic and pulmonary arterial and central venous pressures, heart rate, and cardiac output were monitored, arterial blood was sampled for blood gas tensions and pH, and spinal cord blood flow was determined by colored microsphere injection before and at 15, 60, and 240 min after spinal study drug injection. Results Neostigmine alone did not affect cardiorespiratory variables or spinal cord blood flow. Intrathecal clonidine alone decreased systemic arterial and central venous pressures, whereas these effects were not observed with addition of neostigmine. Clonidine or neostigmine alone or the combination of clonidine and neostigmine did not affect spinal cord blood flow. Conclusions Intrathecal neostigmine alone or in combination with clonidine does not reduce spinal cord blood flow, an important preclinical toxicity issue. These results provide additional support for initial clinical trials of intrathecal neostigmine for analgesia.

The Response of Spinal Cord Blood Flow to High-Dose Barbiturates

Spine ◽  
1982 ◽  
Vol 7 (1) ◽  
pp. 41-45 ◽  
Author(s):  
PATRICK W. HITCHON ◽  
NEAL F. KASSELL ◽  
TODD R. HILL ◽  
MARY K. GERK ◽  
MARTIN D. SOKOLL
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
High Dose ◽  
Spinal Cord Blood Flow

THE EFFECT OF NITROGLYCERIN-INDUCED HYPOTENSION ON SPINAL CORD BLOOD FLOW WITH AND WITHOUT SPINAL DISTRACTION, IN DOGS

1985 ◽  
Vol 63 (Supplement) ◽  
pp. A46
Author(s):  
P. M. Spargo ◽  
T. F. Kling ◽  
A. R. Tait ◽  
R. N. Hensinger ◽  
P. R. Knight
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Spinal Cord Blood Flow ◽  
Induced Hypotension

Effect of altering cerebrospinal fluid pressure on spinal cord blood flow

1994 ◽  
Vol 58 (1) ◽  
pp. 112-115 ◽  
Author(s):  
Shigeru Kazama ◽  
Yoshihiko Masaki ◽  
Shigeyoshi Maruyama ◽  
Akira Ishihara
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cerebrospinal Fluid ◽  
Cord Blood ◽  
Fluid Pressure ◽  
Cerebrospinal Fluid Pressure ◽  
Spinal Cord Blood Flow

Effects of a Contusion Injury on Spinal Cord Blood Flow in the Sheep

Spine ◽  
1984 ◽  
Vol 9 (7) ◽  
pp. 676-680 ◽  
Author(s):  
JOHN D. YEO ◽  
J ROBERT S. HALES ◽  
STEFANIE STABBACK ◽  
S BRADLEY ◽  
ALAN A. FAWCETT ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Spinal Cord Blood Flow ◽  
Contusion Injury

Cerebral and Spinal Cord Blood Flow in Awake and Fentanyl-N2O Anesthetized Rats

1992 ◽  
Vol 4 (1) ◽  
pp. 31-35 ◽  
Author(s):  
William E. Hoffman ◽  
Christian Werner ◽  
Eberhard Kochs ◽  
Larry Segil ◽  
Guy Edelman ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Spinal Cord Blood Flow ◽  
Anesthetized Rats
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