A High Relaxivity Magnetic Resonance Imaging Contrast Agent Targeted to Serum Albumin

2008 ◽  
Vol 61 (9) ◽  
pp. 682 ◽  
Author(s):  
Stéphane Dumas ◽  
Jeffrey S. Troughton ◽  
Normand J. Cloutier ◽  
Jaclyn M. Chasse ◽  
Thomas J. McMurry ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Serum Albumin ◽  
Contrast Agent ◽  
Binding Sites ◽  
Resonance Imaging ◽  
High Relaxivity ◽  
Magnetic Resonance Imaging Contrast ◽  
Magnetic Resonance Angiographic ◽  
Imaging Contrast Agent

EP-647 is a serum albumin-targeted magnetic resonance imaging contrast agent comprising a GdDTPA (DTPA, diethylenetriaminepentaacetate) chelate for magnetic resonance signal generation linked via a phosphodiester to a substituted biphenyl for albumin targeting. Albumin binding and relaxivity are higher than the benchmark magnetic resonance angiographic agent MS-325. EP-647 binds primarily to a unique site on serum albumin that is different from the MS-325 site and the binding sites of other drugs.

scholarly journals Design and Synthesis of a Novel Magnetic Resonance Imaging Contrast Agent for Selective Sensing of Zinc Ion

2002 ◽  
Vol 9 (9) ◽  
pp. 1027-1032 ◽  
Author(s):  
Kenjiro Hanaoka ◽  
Kazuya Kikuchi ◽  
Yasuteru Urano ◽  
Michiko Narazaki ◽  
Takashi Yokawa ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Zinc Ion ◽  
Resonance Imaging ◽  
Design And Synthesis ◽  
Magnetic Resonance Imaging Contrast ◽  
Imaging Contrast Agent

PEGylated chitosan grafted with polyamidoamine-dendron as tumor-targeted magnetic resonance imaging contrast agent

2017 ◽  
Vol 41 (15) ◽  
pp. 7689-7696 ◽  
Author(s):  
Guangyue Zu ◽  
Xiaoyan Tong ◽  
Tingting Zhang ◽  
Yi Cao ◽  
Ye Kuang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Contrast ◽  
Imaging Contrast Agent

PEGylated chitosan grafted with polyamidoamine-dendron was fabricated as a tumor-targeted mCA and its application was well demonstrated.

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