scholarly journals Microtransplantation of neurotransmitter receptors from postmortem autistic brains to Xenopus oocytes

2008 ◽  
Vol 105 (31) ◽  
pp. 10973-10977 ◽  
Author(s):  
A. Limon ◽  
J. M. Reyes-Ruiz ◽  
R. Miledi
Keyword(s):  
Xenopus Oocytes ◽  
Neurotransmitter Receptors

scholarly journals Rapid chemical kinetic techniques for investigations of neurotransmitter receptors expressed in Xenopus oocytes

1996 ◽  
Vol 93 (23) ◽  
pp. 12964-12968 ◽  
Author(s):  
L. Niu ◽  
R. W. Vazquez ◽  
G. Nagel ◽  
T. Friedrich ◽  
E. Bamberg ◽  
...  
Keyword(s):  
Xenopus Oocytes ◽  
Chemical Kinetic ◽  
Neurotransmitter Receptors

scholarly journals Expression of human epileptic temporal lobe neurotransmitter receptors in Xenopus oocytes: An innovative approach to study epilepsy

2002 ◽  
Vol 99 (23) ◽  
pp. 15078-15083 ◽  
Author(s):  
E. Palma ◽  
V. Esposito ◽  
A. M. Mileo ◽  
G. Di Gennaro ◽  
P. Quarato ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Xenopus Oocytes ◽  
Innovative Approach ◽  
Neurotransmitter Receptors

scholarly journals Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes

2002 ◽  
Vol 99 (20) ◽  
pp. 13238-13242 ◽  
Author(s):  
R. Miledi ◽  
F. Eusebi ◽  
A. Martinez-Torres ◽  
E. Palma ◽  
F. Trettel
Keyword(s):  
Human Brain ◽  
Xenopus Oocytes ◽  
Neurotransmitter Receptors ◽  
Brain Membranes

On the orientation of foreign neurotransmitter receptors in Xenopus oocytes

1985 ◽  
Vol 226 (1244) ◽  
pp. 263-269 ◽  
Keyword(s):  
Kainic Acid ◽  
Sodium Channels ◽  
Active Site ◽  
Xenopus Oocytes ◽  
Aminobutyric Acid ◽  
Neurotransmitter Receptors ◽  
Oocyte Membrane

Xenopus oocytes can be made to incorporate into their membrane foreign neurotransmitter receptors and voltage-activated sodium channels. In their original location the receptors are normally activated by the extracellular action of transmitter substances. Tests were made to see if some of the newly synthesized foreign receptors were inserted in the oocyte membrane with their active site facing inwards. Since intracellular injections of acetylcholine, γ -aminobutyric acid, serotonin and kainic acid and tetrodotoxin into the oocyte failed to elicit a response, we conclude that very few, or none, of the receptor molecules expressed in the oocyte by the exogenous mRNA are inserted with the wrong orientation in the membrane.

Sign in / Sign up

Export Citation Format

Share Document