scholarly journals Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies.

1980 ◽  
Vol 77 (10) ◽  
pp. 6114-6118 ◽  
Author(s):  
W. G. Dippold ◽  
K. O. Lloyd ◽  
L. T. Li ◽  
H. Ikeda ◽  
H. F. Oettgen ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Malignant Melanoma ◽  
Cell Surface ◽  
Surface Antigens ◽  
Cell Surface Antigens ◽  
Human Malignant Melanoma ◽  
Definition Of

scholarly journals Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets.

1982 ◽  
Vol 156 (6) ◽  
pp. 1755-1766 ◽  
Author(s):  
A N Houghton ◽  
M Eisinger ◽  
A P Albino ◽  
J G Cairncross ◽  
L J Old
Keyword(s):  
Monoclonal Antibodies ◽  
Malignant Melanoma ◽  
Cell Surface ◽  
Surface Antigens ◽  
New Classification ◽  
Cell Surface Antigens ◽  
Normal Melanocyte ◽  
Early Markers ◽  
Adult Skin

The surface antigens of melanocytes from newborn and adult skin have been analyzed with monoclonal antibodies detecting cell surface antigens of malignant melanoma. Antigenic markers that distinguish early, intermediate, and mature stages in melanocyte differentiation have been defined. The characteristics of the normal melanocyte precursor have been inferred from the features of melanomas that express early markers of melanocyte differentiation. A rudimentary surface antigen map of cells undergoing melanocyte differentiation and a new classification of melanomas based on the expression of melanocyte differentiation antigens are proposed.

scholarly journals Cell surface antigens of human malignant melanoma. III. Recognition of autoantibodies with unusual characteristics.

1977 ◽  
Vol 145 (3) ◽  
pp. 784-789 ◽  
Author(s):  
H Shiku ◽  
T Takahashi ◽  
L A Resnick ◽  
H F Oettgen ◽  
L J Old
Keyword(s):  
Malignant Melanoma ◽  
Cell Surface ◽  
Surface Antigens ◽  
The Other ◽  
Characteristic Pattern ◽  
Cell Populations ◽  
Cell Surface Antigens ◽  
Human Malignant Melanoma ◽  
Immune Adherence ◽  
Specific Antigens

The sera of three patients with malignant melanoma showing reactivity with surface antigens of cultured autologous melanoma cells were analyzed by mixed hemadsorption and immune adherence assays in conjunction with absorption tests. In contrast to the melanoma-specific antigens demonstrated previously, the surface antigens detected by these sera occurred on a broad range of nucleated cells, both normal and malignant, from human, monkey, mouse, and chicken sources. Each serum had a characteristic pattern of reactivity in absorption tests, indicating the detection of distinct antigenic systems. Two sera showed auto-, allo-, and xenoreactivity, as well as the capacity to distinguish different cell populations in the same individual. The other serum reacted with an antigen apparently universally present on nucleated cells from a variety of species, but absent on erythrocytes. As these patients had been treated with chemotherapy, this may have played a role in the emergence of these broadly reactive autoantibodies.

Analysis of cell surface antigens on glucocorticoid-treated rat thymocytes with monoclonal antibodies

1994 ◽  
Vol 39 (3) ◽  
pp. 209-217 ◽  
Author(s):  
M. Tsuchida ◽  
M. Konishi ◽  
K. Jojima ◽  
K. Naito ◽  
Y. Fujikura ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Cell Surface ◽  
Surface Antigens ◽  
Cell Surface Antigens

Protective antigens of bloodstage Plasmodium knowlesi parasites

1984 ◽  
Vol 307 (1131) ◽  
pp. 159-169 ◽  
Keyword(s):  
Monoclonal Antibodies ◽  
Cell Surface ◽  
Plasmodium Knowlesi ◽  
Surface Antigens ◽  
Red Cell ◽  
Cell Surface Antigens ◽  
Susceptible Host ◽  
Protective Antigens ◽  
Stage Of Development

The simian malaria Plasmodium knowlesi provides many favourable features as an experimental model; it can be grown in vivo or in vitro . Parasites of defined variant specificity and stage of development are readily obtained and both the natural host and a highly susceptible host are available for experimental infection and vaccination trials. Proteins synthesized by erythrocytic P. knowlesi parasites are characteristic of the developmental stage, as are the alterations that the parasite induces in the red cell surface. Erythrocytic merozoites are anatomically and biochemically complex, their surface alone is covered by at least eight distinct polypeptides. Immune serum from merozoite-immunized rhesus recognizes many parasite components, especially those synthesized by schizonts. All of the merozoite surface components and some of the schizont-infected red cell surface antigens are recognized by such immune sera. Rhesus monkeys rendered immune by repeated infection may by contrast recognize comparatively few antigens; a positive correlation was established for these ‘ naturally ’ immunized monkeys between protection and antibody directed against a 74000 molecular mass antigen. Im m unization with this purified antigen confers partial protection. O ther putative protective antigens have been identified by monoclonal antibodies that inhibit merozoite invasion of red cells in vitro . The antigens recognized by inhibitory monoclonal antibodies are synthesized exclusively by schizonts and are processed, at the time ofschizont rupture and merozoite release, to smaller molecules that are present on the merozoite surface. The multiplicity of protective antigens is clearly demonstrated by the fact that seven distinct merozoite surface antigens are recognized by three different inhibitory monoclonals. None of the protective antigens identified are variant or strain specific.

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