scholarly journals Relation of cell surface antigens on methylcholanthrene-induced fibrosarcomas to immunoglobulin heavy chain complex variable region-linked T cell interaction molecules

1983 ◽  
Vol 80 (6) ◽  
pp. 1683-1687 ◽  
Author(s):  
P. M. Flood ◽  
A. B. DeLeo ◽  
L. J. Old ◽  
R. K. Gershon
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Heavy Chain ◽  
Complex Variable ◽  
Chain Complex ◽  
Variable Region ◽  
Immunoglobulin Heavy Chain ◽  
Surface Antigens ◽  
Cell Interaction ◽  
Cell Surface Antigens

scholarly journals Human T cell surface antigens bearing a structural relationship to HLA antigens.

1981 ◽  
Vol 78 (6) ◽  
pp. 3858-3862 ◽  
Author(s):  
T. Cotner ◽  
H. Mashimo ◽  
P. C. Kung ◽  
G. Goldstein ◽  
J. L. Strominger
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Hla Antigens ◽  
Surface Antigens ◽  
Structural Relationship ◽  
Cell Surface Antigens ◽  
Human T Cell

scholarly journals Genetic regulation of the antibody response to H-2Db alloantigens in mice. I. Differences in activation of helper T cells in C57BL/10 and BALB/c congenic strains.

1975 ◽  
Vol 141 (3) ◽  
pp. 573-583 ◽  
Author(s):  
D Wernet ◽  
F Lilly
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Antibody Response ◽  
Genetic Regulation ◽  
Surface Antigens ◽  
T Helper ◽  
Spleen Cells ◽  
Igg Antibody ◽  
Cell Surface Antigens ◽  
Helper Function

B10.A(5R) mice immunized with C57BL/10 spleen cells demonstrate a normal T-cell-mediated cytotoxicity to H-2Db tumor cells but they do not mount any IgG antibody response to H-2Db alloantigens. B10.A(5R) mice do show a high titered IgG response when immunized with A.BY cells, which differ at H-2Db plus non-H-2 cell surface antigens, or with B10.A(2R) cells, which differ at H-2Db, H-2Kk, and H-2Ik cell surface antigens. These findings indicate a failure of the T-helper cells to induce the switch from IgM to IgG when the H-2Db alloantigens are the only difference on the immunizing cell. In immunizing H-2d mice with congenic H-g2 cells which differ only in the H-2Db region, mice of the C57BL/10 background made only IgM antibodies whereas mice of the BALB/c background made IgG antibodies. This comparison confirms that genes separate from H-2 regulate the T-cell helper function. The genes that influence the T-cell helper function do not regulate the T-cell-mediated cytotoxicity.

Acute mixed lineage leukemia: clinicopathologic correlations and prognostic significance

Blood ◽  
1985 ◽  
Vol 66 (5) ◽  
pp. 1115-1123 ◽  
Author(s):  
J Mirro ◽  
TF Zipf ◽  
CH Pui ◽  
G Kitchingman ◽  
D Williams ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Induction Therapy ◽  
Gene Rearrangement ◽  
Surface Antigens ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Immunoglobulin Gene ◽  
Cell Surface Antigens ◽  
Immunoglobulin Gene Rearrangement ◽  
Dual Staining

Abstract The frequency and clinical significance of acute leukemia displaying both lymphoid and myeloid characteristics was determined in 123 consecutive children using a panel of lineage-associated markers. The leukemic blasts from 18 of 95 children (19%) with the diagnosis of acute lymphoblastic leukemia (ALL) by standard diagnostic criteria expressed myeloid-associated cell surface antigens. Despite immunological evidence of lymphoid differentiation (17 CALLA + and one T cell-associated antigen +) and findings of immunoglobulin gene rearrangement, blasts from these patients reacted with one to five monoclonal antibodies identifying myeloid-associated cell surface antigens (My-1, MCS.2, Mo1, SJ-D1, or 5F1). Dual staining with microsphere-conjugated antibodies and analysis by flow cytometry confirmed that some blasts were simultaneously expressing lymphoid- and myeloid-associated antigens. Conversely, blasts from seven of 28 patients (25%) with acute nonlymphocytic leukemia (ANLL), diagnosed by otherwise standard morphological and cytochemical criteria, expressed lymphoid-associated surface antigens. Dual staining of individual blasts demonstrated simultaneous expression of myeloperoxidase (MPO) (including Auer rods) in association with either T-11, CALLA, or terminal deoxynucleotidyl transferase. Blasts from one patient with ANLL demonstrated T cell receptor gene rearrangement, while blasts from another patient demonstrated characteristics associated with T (T-11), B (CALLA and heavy-chain immunoglobulin gene rearrangement), and myeloid (MPO) lineage. There were no consistent cytogenetic abnormalities, and no patient demonstrated independent leukemic clones. Each patient with typical ALL, except for myeloid-associated antigens, achieved complete remission with conventional induction therapy for ALL. By contrast, three of the seven children with ANLL whose blasts expressed the T-11 surface antigen failed ANLL induction therapy. These three patients subsequently achieved remission with ALL therapy.

Effect of allograft blood transfusion on Th1/Th2 balance and T cell surface antigens expression

2006 ◽  
Vol 366 (1-2) ◽  
pp. 361-362 ◽  
Author(s):  
Yanning Qian ◽  
Qifeng Tang ◽  
Zhongyun Wang ◽  
Jie Sun ◽  
Qi Li
Keyword(s):  
T Cell ◽  
Blood Transfusion ◽  
Cell Surface ◽  
Surface Antigens ◽  
Cell Surface Antigens

Monoclonal Antibodies against Murine Cell Surface Antigens: Anti-H-2, Anti-Ia and Anti-T Cell Antibodies

1979 ◽  
pp. 100-106
Author(s):  
G. J. Hämmerling ◽  
H. Lemke ◽  
U. Hämmerling ◽  
C. Höhmann ◽  
R. Wallich ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
Cell Surface ◽  
Surface Antigens ◽  
Cell Surface Antigens ◽  
Murine Cell

scholarly journals Localization of aggregated cell surface antigens of target cells bound to cytotoxic T lymphocytes.

1975 ◽  
Vol 142 (4) ◽  
pp. 1011-1016 ◽  
Author(s):  
G Berke ◽  
Z V Fishelson
Keyword(s):  
T Lymphocytes ◽  
Cell Surface ◽  
Cytotoxic T Lymphocytes ◽  
Target Cell ◽  
Cytotoxic T Lymphocyte ◽  
Surface Antigens ◽  
Cell Interaction ◽  
Target Cells ◽  
Cell Surface Antigens ◽  
Polar Localization

The redistribution of aggregated cell surface antigens of target cells bound to cytotoxic T lymphocytes was investigated. It was found that cap formation induced by antibody always occurred toward the site of binding. It is suggested that the polar localization of capped target cell surface determinants is a consequence of cytotoxic T-lymphocyte target cell interaction.

The expression of T-cell surface antigens CTLA-4, CD26, and CD28 is modulated by inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity in murine stress-induced abortions

2002 ◽  
Vol 220 (2) ◽  
pp. 150-156 ◽  
Author(s):  
Jens Rüter ◽  
Torsten Hoffmann ◽  
Ulrich Heiser ◽  
Hans-Ulrich Demuth ◽  
Petra C. Arck ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Surface Antigens ◽  
Cell Surface Antigens ◽  
Dipeptidylpeptidase Iv ◽  
Dpp Iv ◽  
Induced Abortions

scholarly journals Changes of adult T cell leukemia cell surface antigens at relapse or at exacerbation phase after chemotherapy defined by use of monoclonal antibodies

Blood ◽  
1984 ◽  
Vol 64 (2) ◽  
pp. 440-444
Author(s):  
Y Yamada ◽  
S Kamihira ◽  
T Amagasaki ◽  
K Kinoshita ◽  
M Kusano ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
Cell Surface ◽  
Morphological Change ◽  
Surface Antigens ◽  
Leukemic Cells ◽  
Cell Leukemia ◽  
Cell Surface Antigens ◽  
Adult T Cell Leukemia ◽  
Immature Cells

Surface phenotypes of leukemic cells from six patients with adult T cell leukemia (ATL) were analyzed by the use of monoclonal antibodies, both at the time of initial diagnosis and at either relapse or exacerbation phase after chemotherapy. Changes of cell surface antigens were observed in four of the six cases. The majority of the leukemic cells of these patients were reactive with anti-Leu-1 and anti-Leu-3a, but unreactive with anti-Leu-2a and MAS 036c monoclonal antibodies at the time of initial diagnosis, indicating that ATL cells are of peripheral inducer/helper T cell origin. In three cases, the Leu-1 antigen disappeared at relapse or at exacerbation phase, and in one of these cases, a small percentage of ATL cells became reactive with MAS 036c, which identifies cortical thymocyte antigen. ATL cells of one other case did not have Leu-1 antigen from the start, but gained Leu-2a antigen at exacerbation phase and became double-labeled cells (Leu-2a+, 3a+), which is known to be a feature of thymocytes. Thus, it appeared that ATL cells sometimes change their surface phenotype to that of an earlier stage of T cell differentiation at relapse or at exacerbation phase. Chronic myelocytic leukemia (CML) cells also usually change to immature cells at blastic crisis involving morphological change. However, this morphological change was not so prominent in the ATL cases studied, except one, in which typical ATL cells with nuclear indentation changed to large immature cells with basophilic cytoplasm at relapse.

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