scholarly journals An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.

1991 ◽  
Vol 88 (24) ◽  
pp. 11276-11280 ◽  
Author(s):  
T. J. Tsomides ◽  
B. D. Walker ◽  
H. N. Eisen
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Cd8 T Cells ◽  
Class I ◽  
Major Histocompatibility ◽  
Intact Cells ◽  
Viral Peptide ◽  
Histocompatibility Complex ◽  
Major Histocompatibility Complex Protein ◽  
Complex Protein

scholarly journals Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

1992 ◽  
Vol 175 (4) ◽  
pp. 1143-1145 ◽  
Author(s):  
B S Bender ◽  
T Croghan ◽  
L Zhang ◽  
P A Small
Keyword(s):  
T Cells ◽  
Influenza Virus ◽  
Major Histocompatibility Complex ◽  
Transgenic Mice ◽  
Cd8 T Cells ◽  
Viral Clearance ◽  
Class I ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Beta 2

To investigate the role of CD8+ T lymphocytes in recovery from influenza pneumonia, we used transgenic mice either homozygous (-/-) or heterozygous (+/-) for beta 2-microglobulin (beta 2-M) gene disruption. These mice lack major histocompatibility complex-restricted class I (CD8+) T cells. We found that after challenge with a nonlethal influenza virus, the beta 2-M (-/-) mice had significantly delayed pulmonary viral clearance. Furthermore, after challenge with a more virulent influenza virus, the beta 2-M (-/-) mice had a significantly higher mortality rate than did control mice. Thus, CD8+ T cells are important in recovery from virulent influenza infections, but other host defense mechanisms can clear the respiratory tract of more benign infections.

Sign in / Sign up

Export Citation Format

Share Document