scholarly journals Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

1992 ◽  
Vol 175 (4) ◽  
pp. 1143-1145 ◽  
Author(s):  
B S Bender ◽  
T Croghan ◽  
L Zhang ◽  
P A Small
Keyword(s):  
T Cells ◽  
Influenza Virus ◽  
Major Histocompatibility Complex ◽  
Transgenic Mice ◽  
Cd8 T Cells ◽  
Viral Clearance ◽  
Class I ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Beta 2

To investigate the role of CD8+ T lymphocytes in recovery from influenza pneumonia, we used transgenic mice either homozygous (-/-) or heterozygous (+/-) for beta 2-microglobulin (beta 2-M) gene disruption. These mice lack major histocompatibility complex-restricted class I (CD8+) T cells. We found that after challenge with a nonlethal influenza virus, the beta 2-M (-/-) mice had significantly delayed pulmonary viral clearance. Furthermore, after challenge with a more virulent influenza virus, the beta 2-M (-/-) mice had a significantly higher mortality rate than did control mice. Thus, CD8+ T cells are important in recovery from virulent influenza infections, but other host defense mechanisms can clear the respiratory tract of more benign infections.

CROSS-REACTIVITY OF CYTOMEGALOVIRUS-SPECIFIC CD8+ T CELLS TO ALLO-MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I MOLECULES

2004 ◽  
Vol 77 (12) ◽  
pp. 1879-1885 ◽  
Author(s):  
Laila E. Gamadia ◽  
Ester B. Remmerswaal ◽  
Sugianto Surachno ◽  
Neubury M. Lardy ◽  
Pauline M. Wertheim-van Dillen ◽  
...  
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Cd8 T Cells ◽  
Cross Reactivity ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

scholarly journals Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.

1991 ◽  
Vol 174 (4) ◽  
pp. 875-880 ◽  
Author(s):  
M Eichelberger ◽  
W Allan ◽  
M Zijlstra ◽  
R Jaenisch ◽  
P C Doherty
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Respiratory Tract ◽  
Influenza A Virus ◽  
Influenza A ◽  
Class I ◽  
Major Histocompatibility ◽  
Class I Mhc ◽  
Histocompatibility Complex ◽  
Beta 2

Transgenic mice homozygous for a beta 2-microglobulin (beta 2-m) gene disruption and normal mice that had been treated with a CD8-specific mAb were infected intranasally with an H3N2 influenza A virus. Both groups of CD8T cell-deficient mice eliminated the virus from the infected respiratory tract. Potent CTL activity was detected in lung lavage populations taken from mice with intact CD8+ T cell function, with minimal levels of cytotoxicity being found for inflammatory cells obtained from the antibody-treated and beta 2-m mutant mice. We therefore conclude that cells infected with an influenza A virus can be cleared from the respiratory tract of mice lacking both functional class I major histocompatibility complex (MHC) glycoproteins and class I MHC-restricted, CD8+ effector T cells.

Sign in / Sign up

Export Citation Format

Share Document