scholarly journals Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

1991 ◽  
Vol 88 (5) ◽  
pp. 1788-1792 ◽  
Author(s):  
U. Forstermann ◽  
J. S. Pollock ◽  
H. H. Schmidt ◽  
M. Heller ◽  
F. Murad
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Nitric Oxide Synthase ◽  
Aortic Endothelial Cells ◽  
Relaxing Factor ◽  
Bovine Aortic Endothelial Cells ◽  
Endothelium Derived Relaxing Factor ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity ◽  
Aortic Endothelial

scholarly journals Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells

1992 ◽  
Vol 281 (2) ◽  
pp. 297-300 ◽  
Author(s):  
K Schmidt ◽  
E R Werner ◽  
B Mayer ◽  
H Wachter ◽  
W R Kukovetz
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Inhibitory Effect ◽  
Salvage Pathway ◽  
Aortic Endothelial Cells ◽  
Relaxing Factor ◽  
Endothelium Derived Relaxing Factor ◽  
Aortic Endothelial

Inhibition of tetrahydrobiopterin (H4biopterin) biosynthesis in endothelial cells almost completely abolished the agonist-induced formation of endothelium-derived relaxing factor (EDRF) (NO). This inhibitory effect could be antagonized when H4biopterin biosynthesis was restored by activating a salvage pathway. These data indicate that the formation of EDRF strictly depends on the presence of intracellular H4biopterin, which, in addition to Ca2+, may represent a further physiological and/or pathophysiological regulatory of endothelial NO synthases.

Monocyte-Induced Downregulation of Nitric Oxide Synthase in Cultured Aortic Endothelial Cells

1996 ◽  
Vol 16 (9) ◽  
pp. 1095-1103 ◽  
Author(s):  
Nándor Marczin ◽  
Alexander Antonov ◽  
Andreas Papapetropoulos ◽  
David H. Munn ◽  
Renu Virmani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Nitric Oxide Synthase ◽  
Aortic Endothelial Cells ◽  
Oxide Synthase ◽  
Aortic Endothelial
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