scholarly journals DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors.

1993 ◽  
Vol 90 (17) ◽  
pp. 8131-8135 ◽  
Author(s):  
A. Y. Chen ◽  
C. Yu ◽  
B. Gatto ◽  
L. F. Liu
Keyword(s):  
Topoisomerase I ◽  
Minor Groove ◽  
Dna Topoisomerase I ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Topoisomerase ◽  
Dna Minor Groove ◽  
Topoisomerase I Inhibitors

DNA Minor Groove Binding-Directed Poisoning of Human DNA Topoisomerase I by Terbenzimidazoles†

Biochemistry ◽  
1998 ◽  
Vol 37 (10) ◽  
pp. 3558-3566 ◽  
Author(s):  
Zhitao Xu ◽  
Tsai-Kun Li ◽  
Jung Sun Kim ◽  
Edmond J. LaVoie ◽  
Kenneth J. Breslauer ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Minor Groove ◽  
Dna Topoisomerase I ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Topoisomerase ◽  
Dna Minor Groove ◽  
Human Dna ◽  
Human Dna Topoisomerase I

scholarly journals Human DNA-topoisomerase I activity is affected by bis-netropsin's binding to DNA minor groove

IUBMB Life ◽  
1998 ◽  
Vol 44 (5) ◽  
pp. 997-1010
Author(s):  
Alyona Sukhanova ◽  
Sergei Grokhovsky ◽  
Alexei Zhuze ◽  
David Roper ◽  
Igor Bronstein
Keyword(s):  
Topoisomerase I ◽  
Minor Groove ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Dna Minor Groove ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Inhibition of Human DNA Topoisomerase I by New DNA Minor Groove Ligands: Derivatives of Oligo-1,3-Thiazolecarboxamides

2001 ◽  
Vol 11 (3) ◽  
pp. 137-147 ◽  
Author(s):  
Dmitry V. Bugreev ◽  
Elena L. Vasyutina ◽  
Vladimir A. Ryabinin ◽  
Alexander N. Sinyakov ◽  
Valentina N. Buneva ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Minor Groove ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Dna Minor Groove ◽  
Human Dna ◽  
Derivatives Of ◽  
Human Dna Topoisomerase I

scholarly journals Antineoplastic DNA-Binding Compounds: Intercalating and Minor Groove Binding Drugs

2013 ◽  
Vol 64 (4) ◽  
pp. 593-602 ◽  
Author(s):  
Katarina Mišković ◽  
Maro Bujak ◽  
Mirela Baus Lončar ◽  
Ljubica Glavaš-Obrovac
Keyword(s):  
Topoisomerase I ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Minor Groove ◽  
Chemical Structures ◽  
Minor Groove Binders ◽  
Naturally Occurring ◽  
Groove Binders ◽  
Proliferating Cell

Abstract DNA intercalating and minor groove binding compounds are new weapons in the battle against malignant diseases. These antineoplastic agents target the DNA molecule and interfere with the cell cycle leading to rapidly proliferating cell death. They are mainly derivates of a naturally occurring organic compound derived from a microorganism or plant. Intercalators usually act as topoisomerase I and/or II poisons, while the mechanisms of DNA minor groove binders are a combination of several steps including topoisomerase poisoning. This paper gives an overview of some of the developed DNA intercalating and minor groove binding compounds, as well as an explanation of their chemical structures, origins, and application in chemotherapy.

Minor groove dimeric bisbenzimidazoles inhibit in vitro DNA binding to eukaryotic DNA topoisomerase I

2010 ◽  
Vol 75 (6) ◽  
pp. 695-701 ◽  
Author(s):  
O. Yu. Susova ◽  
A. A. Ivanov ◽  
S. S. Morales Ruiz ◽  
E. A. Lesovaya ◽  
A. V. Gromyko ◽  
...  
Keyword(s):  
Dna Binding ◽  
Topoisomerase I ◽  
Minor Groove ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Dimeric Bisbenzimidazoles ◽  
Eukaryotic Dna

Influence of GC and AT Specific DNA Minor Groove Binding Drugs on Intermolecular Triplex Formation in the Human c-Ki-ras Promoter†

Biochemistry ◽  
1996 ◽  
Vol 35 (4) ◽  
pp. 1106-1114 ◽  
Author(s):  
Nadarajah Vigneswaran ◽  
Charles A. Mayfield ◽  
Brad Rodu ◽  
Roger James ◽  
H.-G. Kim ◽  
...  
Keyword(s):  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Minor Groove ◽  
Triplex Formation
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