Minor groove dimeric bisbenzimidazoles inhibit in vitro DNA binding to eukaryotic DNA topoisomerase I

2010 ◽  
Vol 75 (6) ◽  
pp. 695-701 ◽  
Author(s):  
O. Yu. Susova ◽  
A. A. Ivanov ◽  
S. S. Morales Ruiz ◽  
E. A. Lesovaya ◽  
A. V. Gromyko ◽  
...  
Keyword(s):  
Dna Binding ◽  
Topoisomerase I ◽  
Minor Groove ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Dimeric Bisbenzimidazoles ◽  
Eukaryotic Dna

Genotoxic potentials and eukaryotic DNA topoisomerase I inhibitory effects of some benzoxazine derivatives

2013 ◽  
Vol 23 (1) ◽  
pp. 480-486 ◽  
Author(s):  
Fatma Zilifdar ◽  
Sabiha Alper-Hayta ◽  
Serap Yilmaz ◽  
Çiğdem Kaplan-Özen ◽  
Egemen Foto ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Inhibitory Effects ◽  
Dna Topoisomerase ◽  
Eukaryotic Dna

Synthesis, crystal structure, DNA interaction and in vitro anticancer activity of a Cu(ii) complex of purpurin: dual poison for human DNA topoisomerase I and II

RSC Advances ◽  
2014 ◽  
Vol 4 (103) ◽  
pp. 59344-59357 ◽  
Author(s):  
Piyal Das ◽  
Chetan Kumar Jain ◽  
Sanjoy K. Dey ◽  
Rajat Saha ◽  
Abhishek Dutta Chowdhury ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Topoisomerase I ◽  
Dna Interaction ◽  
Dna Topoisomerase I ◽  
Oxygen Species ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Anti Tumor Activity ◽  
Human Dna Topoisomerase I

Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic.

DNA recombinase activity of eukaryotic DNA topoisomerase I; effects of camptothecin and other inhibitors

1995 ◽  
Vol 337 (2) ◽  
pp. 135-145 ◽  
Author(s):  
Yves Pommier ◽  
Jeffrey Jenkins ◽  
Glenda Kohlhagen ◽  
François Leteurtre
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Eukaryotic Dna ◽  
Dna Recombinase

scholarly journals Nucleosomes represent a physical barrier for cleavage activity of DNA topoisomerase I in vivo

2008 ◽  
Vol 409 (3) ◽  
pp. 651-656 ◽  
Author(s):  
Francesca Di Felice ◽  
Francesco Chiani ◽  
Giorgio Camilloni
Keyword(s):  
Topoisomerase I ◽  
Basic Question ◽  
Dna Topoisomerase I ◽  
Physical Barrier ◽  
Dna Topoisomerase ◽  
Histone Octamer ◽  
Cleavage Activity ◽  
Cellular Dna

DNA topoisomerase I together with the other cellular DNA topoisomerases releases the torsional stress from DNA caused by processes such as replication, transcription and recombination. Despite the well-defined knowledge of its mechanism of action, DNA topoisomerase I in vivo activity has been only partially characterized. In fact the basic question concerning the capability of the enzyme to cleave and rejoin DNA wrapped around a histone octamer remains still unanswered. By studying both in vivo and in vitro the cleavage activity of DNA topoisomerase I in the presence of camptothecin on a repeated trinucleotide sequence, (TTA)35, lying in chromosome XIII of Saccharomyces cerevisiae, we can conclude that nucleosomes represent a physical barrier for the enzyme activity.

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